Role of EGFL7 in human cancers: A review

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBarretos Cancer Hospital-
Autor(es): dc.contributorDr Paulo Prata – FACISB-
Autor(es): dc.creatorde Oliveira, Cristiane-
Autor(es): dc.creatorGonçalves, Paola Gyuliane-
Autor(es): dc.creatorBidinotto, Lucas Tadeu-
Data de aceite: dc.date.accessioned2025-08-21T22:48:00Z-
Data de disponibilização: dc.date.available2025-08-21T22:48:00Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jcp.31084-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297049-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297049-
Descrição: dc.descriptionEGFL7 is a proangiogenic factor. It has been widely described with having a vital role in tubulogenesis and regulation of angiogenesis, mainly during embryogenesis and organogenesis. It has been mainly associated with NOTCH pathway, but there are reports showing association with MAPK and integrin pathways. Given its association with angiogenesis and these other pathways, there are several studies associating EGFL7 with carcinogenesis. In fact, most of the studies have pointed to EGFL7 as an oncogene, and some of them suggest EGFL7 expression as a possible biomarker of prognosis or use for a patient's follow-up. Here, we review the molecular pathways which EGFL7 is associated and highlight several studies describing the role of EGFL7 in tumorigenesis, separated by tumor type. Besides its role on angiogenesis, EGFL7 may act in other pathways as oncogene, which makes it a possible biomarker and a candidate to targeted therapy.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (Unesp), São Paulo-
Descrição: dc.descriptionMolecular Oncology Research Center Barretos Cancer Hospital, São Paulo-
Descrição: dc.descriptionHuman and Experimental Biology Department Barretos School of Health Sciences Dr Paulo Prata – FACISB, São Paulo-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School São Paulo State University (Unesp), São Paulo-
Descrição: dc.descriptionFAPESP: 2021/14253-4-
Formato: dc.format1756-1767-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cellular Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectangiogenesis-
Palavras-chave: dc.subjectcancer-
Palavras-chave: dc.subjectEGFL7-
Palavras-chave: dc.subjectpathways-
Título: dc.titleRole of EGFL7 in human cancers: A review-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.