Discovery of Novel Inhibitors of Cruzain Cysteine Protease of Trypanosoma cruzi

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAdvanced Research Center in Medicine-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorPrates, João Lucas Bruno-
Autor(es): dc.creatorLopes, Juliana Romano-
Autor(es): dc.creatorChin, Chung Man-
Autor(es): dc.creatorFerreira, Elizabeth Igne-
Autor(es): dc.creatorDos Santos, Jean Leandro-
Autor(es): dc.creatorScarim, Cauê Benito-
Data de aceite: dc.date.accessioned2025-08-21T16:03:55Z-
Data de disponibilização: dc.date.available2025-08-21T16:03:55Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/0109298673254864230921090519-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297042-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297042-
Descrição: dc.descriptionChagas disease (CD) is a parasitic disease endemic in several developing countries. According to the World Health Organization, approximately 6-8 million people worldwide are inflicted by CD. The scarcity of new drugs, mainly for the chronic phase, is the main reason for treatment limitation in CD. Therefore, there is an urgent need to discover new targets for which new therapeutical agents could be developed. Cruzain cysteine protease (CCP) is a promising alternative because this enzyme exhibits pleiotropic effects by acting as a virulence factor, modulating host immune cells, and interacting with host cells. This systematic review was conducted to discover new compounds that act as cruzain inhibitors, and their effects in vitro were studied through enzymatic assays and molecular docking. Additionally, the advances and perspectives of these inhibitors are discussed. These findings are expected to contribute to medicinal chemistry in view of the design of new, safe, and efficacious inhibitors against Trypanosoma cruzi CCP detected in the last decade (2013-2022) to provide scaffolds for further optimization, aiming toward the discovery of new drugs.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Drugs and Medicine School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionChemistry Institute Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionUnion of the Colleges of the Great Lakes (UNILAGO) School of Medicine Advanced Research Center in Medicine, SP-
Descrição: dc.descriptionLAPEN-Laboratory of Design and Synthesis of Chemotherapeutic Agents Potentially Active on Neglected Diseases Department of Pharmacy School of Pharmaceutical Sciences University of São Paulo (USP), SP-
Descrição: dc.descriptionDepartment of Drugs and Medicine School of Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionChemistry Institute Araraquara São Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 001-
Descrição: dc.descriptionFAPESP: 2020/13279-7-
Descrição: dc.descriptionCAPES: 302689/2020-6-
Descrição: dc.descriptionCNPq: 302689/2020-6-
Formato: dc.format2285-2308-
Idioma: dc.languageen-
Relação: dc.relationCurrent Medicinal Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChagas disease-
Palavras-chave: dc.subjectcruzain-
Palavras-chave: dc.subjectCysteine proteases-
Palavras-chave: dc.subjectdrug development-
Palavras-chave: dc.subjectnew compounds-
Palavras-chave: dc.subjectT. cruzi-
Título: dc.titleDiscovery of Novel Inhibitors of Cruzain Cysteine Protease of Trypanosoma cruzi-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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