Feasible low bone density condition for assessing bioactivity in ex-in vivo and in vivo studies

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCollege of Dentistry-
Autor(es): dc.creatorDa Silva, William Phillip Pereira-
Autor(es): dc.creatorDelanora, Leonardo Alan-
Autor(es): dc.creatorRios, Barbara Ribeiro-
Autor(es): dc.creatorBarbosa, Stéfany-
Autor(es): dc.creatorSimon, Maria Eloise de Sá-
Autor(es): dc.creatorSukotjo, Cortino-
Autor(es): dc.creatorFaverani, Leonardo Perez-
Data de aceite: dc.date.accessioned2025-08-21T19:35:47Z-
Data de disponibilização: dc.date.available2025-08-21T19:35:47Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1678-7757-2022-0411-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297037-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297037-
Descrição: dc.descriptionObjective: To choose a critical animal model for assessments of bone repair with implant installation by comparing senile rats (SENIL) to young ovariectomized rats (OXV). Methodology: For the ex-in vivo study, the femurs were precursors for bone marrow mesenchymal stem cells. Cellular responses were performed, including cell viability, gene expression of osteoblastic markers, bone sialoprotein immunolocalization, alkaline phosphatase activity, and mineralized matrix formation. For the in vivo study, the animals received implants in the region of the bilateral tibial metaphysis for histometric, microtomography, reverse torque, and confocal microscopy. Results: Cell viability showed that the SENIL group had lower growth than OVX. Gene expression showed more critical responses for the SENIL group (p<0.05). The alkaline phosphatase activity obtained a lower expression in the SENIL group, as for the mineralization nodules (p<0.05). The in vivo histological parameters and biomechanical analysis showed lower data for the SENIL group. The confocal microscopy indicated the presence of a fragile bone in the SENIL group. The microtomography was similar between the groups. The histometry of the SENIL group showed the lowest values (p<0.05). Conclusion: In experimental studies with assessments of bone repair using implant installation, the senile model promotes the most critical bone condition, allowing a better investigation of the properties of biomaterials and topographic changes.-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Diagnóstico e Cirurgia-
Descrição: dc.descriptionUniversity of Illinois at Chicago College of Dentistry Department of Restorative Dentistry-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Diagnóstico e Cirurgia-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Oral Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAging-
Palavras-chave: dc.subjectAnimal models-
Palavras-chave: dc.subjectBone remodeling-
Palavras-chave: dc.subjectOsteoporosis-
Título: dc.titleFeasible low bone density condition for assessing bioactivity in ex-in vivo and in vivo studies-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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