Experimental apical periodontitis alters salivary biochemical composition and induces local redox state disturbances in the salivary glands of male rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do Pará (UFPA)-
Autor(es): dc.creatorVazão, Arieli Raymundo-
Autor(es): dc.creatorClaudino, Lívia-
Autor(es): dc.creatorPimpinato, Pedro Penati-
Autor(es): dc.creatorSampaio, Larissa Victorino-
Autor(es): dc.creatorFiais, Gabriela Alice-
Autor(es): dc.creatorde Freitas, Rayara Nogueira-
Autor(es): dc.creatorJusto, Mariana Pagliusi-
Autor(es): dc.creatorBrito, Victor Gustavo Balera-
Autor(es): dc.creatorOliveira, Sandra Helena Penha de-
Autor(es): dc.creatorLima, Rafael Rodrigues-
Autor(es): dc.creatorCintra, Luciano Tavares Ângelo-
Autor(es): dc.creatorChaves-Neto, Antonio Hernandes-
Data de aceite: dc.date.accessioned2025-08-21T15:32:28Z-
Data de disponibilização: dc.date.available2025-08-21T15:32:28Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-024-05540-6-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297028-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297028-
Descrição: dc.descriptionObjectives: The objective was to evaluate the effects of experimental apical periodontitis on the inflammatory, functional, biochemical, and redox parameters of the parotid and submandibular glands in rats. Materials and methods: Twenty 12-week-old male Wistar rats were randomly divided into two groups (n = 10): a control group and apical periodontitis group. After 28 days, the saliva was collected for salivary flow rate and biochemistry composition. Both glands were sampled for quantification of the tumor necrosis factor-alpha (TNF-α) and biochemical analyses of redox state. Results: TNF-α concentrations were higher in both salivary glands adjacent to the periapical lesions in animals with apical periodontitis and also compared to the control group. The apical periodontitis group increased the salivary amylase, chloride, potassium, calcium, and phosphate. The total oxidant capacity increased in the parotid gland adjacent to the periapical lesions in the same rat and compared to the control group. Conversely, the total antioxidant capacity of the parotid glands on both sides in the apical periodontitis group was lower than that in the control group. Furthermore, glutathione peroxidase activity increased in the submandibular gland adjacent to the apical periodontitis group compared to the control group. Conclusions: Experimental apical periodontitis alters salivary biochemical composition, in addition to increasing inflammatory marker and inducing local disturbances in the redox state in the parotid and submandibular glands of male rats. Clinical relevance: Apical periodontitis could exacerbate the decline in oral health by triggering dysfunction in the salivary glands.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências School of Dentistry of Araçatuba–UNESP–Universidade Estadual Paulista-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry of Araçatuba–UNESP–Universidade Estadual Paulista-
Descrição: dc.descriptionPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas–SBFis School of Dentistry of Araçatuba–UNESP–Universidade Estadual Paulista-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry of Araçatuba–UNESP–Universidade Estadual Paulista-
Descrição: dc.descriptionLaboratory of Functional and Structural Biology Institute of Biological Sciences Federal University of Pará (UFPA)-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências School of Dentistry of Araçatuba–UNESP–Universidade Estadual Paulista-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry of Araçatuba–UNESP–Universidade Estadual Paulista-
Descrição: dc.descriptionPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas–SBFis School of Dentistry of Araçatuba–UNESP–Universidade Estadual Paulista-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry of Araçatuba–UNESP–Universidade Estadual Paulista-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2022/11532-2-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectApical periodontitis-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectSaliva-
Palavras-chave: dc.subjectSalivary glands-
Palavras-chave: dc.subjectSalivary proteins and peptides-
Título: dc.titleExperimental apical periodontitis alters salivary biochemical composition and induces local redox state disturbances in the salivary glands of male rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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