Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Rio Grande do Norte (UFRN)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorCabral, Bárbara-
Autor(es): dc.creatorGaldino, Ony Araújo-
Autor(es): dc.creatorde Souza Gomes, Iago-
Autor(es): dc.creatorAlves, Jovelina Samara Ferreira-
Autor(es): dc.creatorMarques, José Ivan-
Autor(es): dc.creatorSouza, Karla Simone Costa de-
Autor(es): dc.creatorda Silva, Rodrigo Moreira-
Autor(es): dc.creatorAbreu, Bento João-
Autor(es): dc.creatorLopes, Norberto Peporine-
Autor(es): dc.creatorZucolotto, Silvana Maria-
Autor(es): dc.creatorRezende, Adriana Augusto de-
Data de aceite: dc.date.accessioned2025-08-21T16:11:57Z-
Data de disponibilização: dc.date.available2025-08-21T16:11:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jff.2024.106638-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/297007-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/297007-
Descrição: dc.descriptionThe study investigated the potential benefits of passion fruit peel extracts (PFAE and PFHE), derived from Passiflora edulis fo. flavicarpa, for Type 1 Diabetes mellitus (T1DM). Extracts were produced using eco-friendly solvents and evaluated in a T1DM chronic model. Acute toxicity tests showed the extracts (2000 mg/kg, orally) were safe. Liquid chromatography coupled to triple quadrupole mass spectrometry (LC-QqQ-MS/MS) identified five C-glycosylated flavonoids (vicenin-2, orientin, isoorientin, vitexin, isovitexin) in the extracts. Adjuvant treatment with extracts alongside insulin significantly improved glycemic control over 60 days compared to insulin alone (p < 0.05). Furthermore, extracts protected against renal fibrosis and maintenance of the levels of inflammatory markers, such as myeloperoxidase, in the hearts and kidneys of diabetic rats. These findings suggest passion fruit peel extracts could enhance long-term T1DM management by improving glycemic control and preventing organ damage, potentially inspiring the development of new food or pharmaceutical products with beneficial actions for T1DM.-
Descrição: dc.descriptionGraduate Program in Pharmaceutical Sciences Federal University of Rio Grande do Norte (UFRN), RN-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses Federal University of Rio Grande do Norte (UFRN), RN-
Descrição: dc.descriptionDepartment of Morphology Federal University of Rio Grande do Norte (UFRN), RN-
Descrição: dc.descriptionGraduate Program in Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Biomolecular Sciences Faculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (USP), SP-
Descrição: dc.descriptionGraduate Program in Health Sciences Federal University of Rio Grande do Norte (UFRN), RN-
Descrição: dc.descriptionGraduate Program in Pharmaceutical Sciences São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Functional Foods-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntidiabetic agents-
Palavras-chave: dc.subjectFlavonoids-
Palavras-chave: dc.subjectFruit peel-
Palavras-chave: dc.subjectPassiflora edulis-
Palavras-chave: dc.subjectSafety-
Título: dc.titleBioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats with type 1 Diabetes mellitus-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.