Metabolomic Profiling of Guadua Species and Its Correlation with Antioxidant and Cytotoxic Activities

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPontificia Universidad Javeriana-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidad Nacional de Colombia-
Autor(es): dc.creatorChitiva, Luis Carlos-
Autor(es): dc.creatorRezende-Teixeira, Paula-
Autor(es): dc.creatorLeão, Tiago F.-
Autor(es): dc.creatorLozano-Puentes, Hair Santiago-
Autor(es): dc.creatorLondoño, Ximena-
Autor(es): dc.creatorDíaz-Ariza, Lucía Ana-
Autor(es): dc.creatorCosta-Lotufo, Leticia V.-
Autor(es): dc.creatorPrieto-Rodríguez, Juliet A.-
Autor(es): dc.creatorCosta, Geison M.-
Autor(es): dc.creatorCastro-Gamboa, Ian-
Data de aceite: dc.date.accessioned2025-08-21T21:37:08Z-
Data de disponibilização: dc.date.available2025-08-21T21:37:08Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-03-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acsomega.3c09114-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/296869-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/296869-
Descrição: dc.descriptionBamboo plants are widely used in Asian traditional medicine for various health issues and exhibit therapeutic potential. Guadua species are renowned bamboos for their high phenolic compound content, including flavonoids and hydroxycinnamic acid derivatives, and possess noteworthy biological properties. Despite this, there is a notable scarcity of research on the chemical and biological aspects of Latin American bamboo leaf extracts (BLEs), especially concerning the Guadua genus. This study aimed to employ a metabolomics approach to integrate the phytochemical and activity profiles of BLEs to identify potential bioactive markers. We determined the metabolic fingerprints of 30 BLEs through HPTLC, HPLC-DAD, UHPLC-QTOF-MS, and 1H-NMR analyses and screened for antioxidant and cytotoxic activities using ABTS, DPPH, and MTT methods. Ultimately, correlation analyses were performed by using chemometric methods and molecular networking. Our findings present a comprehensive chemical characterization, encompassing 40 flavonoids and 9 cinnamic acid derivatives. Notably, most of these compounds have been reported for the first time within the genus, signifying novel discoveries. Additionally, certain compounds identified in other species of the subfamily Bambusoideae provide valuable comparative insights. These compounds demonstrated a significant correlation with antioxidant potential, with values exceeding 100 and 30 μmol of TE/g of extract for ABTS and DPPH, respectively, in the samples. Extracts from G. incana and G. angustifolia exhibited potent cytotoxic effects with IC50 values of 1.23 and 4.73 μg/mL against HCT-116 colon cancer cells, respectively. Notably, glycosylated flavones showed a strong correlation with cytotoxicity. These new findings significantly contribute to our understanding of the chemical composition and biological properties of these often overlooked bamboo species, providing them with important added value and alternative use.-
Descrição: dc.descriptionNúcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Institute of Chemistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionGrupo de Investigación Fitoquímica Universidad Javeriana (GIFUJ) Department of Chemistry Faculty of Sciences Pontificia Universidad Javeriana-
Descrição: dc.descriptionLaboratório de Farmacologia de Produtos Naturais Marinhos Institute of Biomedical Sciences University of São Paulo, São Paulo-
Descrição: dc.descriptionLaboratorio Asociaciones Suelo Planta Microorganismo (LAMIC) Grupo de Investigación en Agricultura Biológica Department of Biology Faculty of Sciences Pontificia Universidad Javeriana-
Descrição: dc.descriptionFaculty of Agricultural Sciences Universidad Nacional de Colombia-
Descrição: dc.descriptionNúcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Institute of Chemistry São Paulo State University (UNESP), São Paulo-
Formato: dc.format36939-36960-
Idioma: dc.languageen-
Relação: dc.relationACS Omega-
???dc.source???: dc.sourceScopus-
Título: dc.titleMetabolomic Profiling of Guadua Species and Its Correlation with Antioxidant and Cytotoxic Activities-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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