Fatuamide A, a Hybrid PKS/NRPS Metallophore from a Leptolyngbya sp. Marine Cyanobacterium Collected in American Samoa

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Autor(es): dc.contributorUniversity of California-
Autor(es): dc.contributorSan Diego Botanic Garden-
Autor(es): dc.contributorKeio University-
Autor(es): dc.contributorUniversità degli Studi di Napoli Federico II-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPhilipps-University Marburg-
Autor(es): dc.contributorUniversity of Tuebingen-
Autor(es): dc.contributorRiverside-
Autor(es): dc.contributorDongguk University-
Autor(es): dc.contributorUMR 7093-
Autor(es): dc.contributorMedical Sciences Campus-
Autor(es): dc.creatorAlexander, Kelsey L.-
Autor(es): dc.creatorNaman, C. Benjamin-
Autor(es): dc.creatorIwasaki, Arihiro-
Autor(es): dc.creatorMangoni, Alfonso-
Autor(es): dc.creatorLeao, Tiago-
Autor(es): dc.creatorReher, Raphael-
Autor(es): dc.creatorPetras, Daniel-
Autor(es): dc.creatorKim, Hyunwoo-
Autor(es): dc.creatorTernon, Eva-
Autor(es): dc.creatorCaro-Diaz, Eduardo J. E.-
Autor(es): dc.creatorGlukhov, Evgenia-
Autor(es): dc.creatorMitrevska, Jana A.-
Autor(es): dc.creatorAvalon, Nicole E.-
Autor(es): dc.creatorDuggan, Brendan M.-
Autor(es): dc.creatorGerwick, Lena-
Autor(es): dc.creatorGerwick, William H.-
Data de aceite: dc.date.accessioned2025-08-21T15:15:35Z-
Data de disponibilização: dc.date.available2025-08-21T15:15:35Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.jnatprod.4c01051-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/296865-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/296865-
Descrição: dc.descriptionA structurally novel metabolite, fatuamide A (1), was discovered from a laboratory cultured strain of the marine cyanobacterium Leptolyngbya sp., collected from Faga’itua Bay, American Samoa. A bioassay-guided approach using NCI-H460 human lung cancer cells directed the isolation of fatuamide A, which was obtained from the most cytotoxic fraction. The planar structure of fatuamide A was elucidated by integrated NMR and MS/MS analysis, and a combination of bioinformatic and computational approaches was used to deduce the absolute configuration at its eight stereocenters. A putative hybrid PKS/NRPS biosynthetic gene cluster responsible for fatuamide A production was identified from the sequenced genomic DNA of the cultured cyanobacterium. The biosynthetic gene cluster possessed elements that suggested fatuamide A binds metals, and this metallophore property was demonstrated by native metabolomics and indicated a preference for binding copper. The producing strain was found to be highly resistant to toxicity from elevated copper concentrations in culture media.-
Descrição: dc.descriptionCenter for Marine Biotechnology and Biomedicine Scripps Institution of Oceanography University of California-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry University of California-
Descrição: dc.descriptionDepartment of Science and Conservation San Diego Botanic Garden-
Descrição: dc.descriptionDepartment of Chemistry Faculty of Science and Technology Keio University, 3-14-1 Hiyoshi, Kanagawa-
Descrição: dc.descriptionDipartimento di Farmacia Università degli Studi di Napoli Federico II, via, Domenico Montesano 49-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSkaggs School of Pharmacy and Pharmaceutical Sciences University of California-
Descrição: dc.descriptionInstitute for Pharmaceutical Biology and Biotechnology Department of Pharmacy Philipps-University Marburg, Robert-Koch-Straße 4-
Descrição: dc.descriptionInterfaculty Institute of Microbiology and Infection Medicine University of Tuebingen-
Descrição: dc.descriptionDepartment of Biochemistry University of California Riverside-
Descrição: dc.descriptionCollege of Pharmacy Dongguk University-
Descrição: dc.descriptionSorbonne Université CNRS Laboratoire d’Océanographie de Villefranche UMR 7093-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences School of Pharmacy University of Puerto Rico Medical Sciences Campus-
Descrição: dc.descriptionInstitute of Chemistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Natural Products-
???dc.source???: dc.sourceScopus-
Título: dc.titleFatuamide A, a Hybrid PKS/NRPS Metallophore from a Leptolyngbya sp. Marine Cyanobacterium Collected in American Samoa-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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