Opioid mu-receptors in the rostral medullary raphe modulate hypoxia-induced hyperpnea in unanesthetized rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDias, M. B.-
Autor(es): dc.creatorNucci, T. B.-
Autor(es): dc.creatorBranco, L. G. S.-
Autor(es): dc.creatorGargaglioni, L. H.-
Data de aceite: dc.date.accessioned2021-03-10T16:36:16Z-
Data de disponibilização: dc.date.available2021-03-10T16:36:16Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2012-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/j.1748-1716.2011.02345.x-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/2762-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/2762-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionINCT-Fisiologia Comparada-
Descrição: dc.descriptionPrograma de Apoio aos Núcleos de Excelência (PRONEX)-
Descrição: dc.descriptionAim: It has been suggested that the medullary raphe (MR) plays a key role in the physiological responses to hypoxia. As opioid mu-receptors have been found in the MR, we studied the putative role of opioid mu-receptors in the rostral MR (rMR) region on ventilation in normal and 7% hypoxic conditions.Methods: We measured pulmonary ventilation ((V) over dotE) and the body temperatures (Tb) of male Wistar rats before and after the selective opioid l-receptor antagonist CTAP ( d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2, cyclic, 0.1 mu g per 0.1 mu L) was microinjected into the rMR during normoxia or after 60 min of hypoxia.Results: The animals treated with intra-rMR CTAP exhibited an attenuation of the ventilatory response to hypoxia ( 430 +/- 86 mL kg) 1 min) 1) compared with the control group ( 790 +/- 82 mL kg) 1 min) 1) ( P < 0.05). No differences in the Tb were observed between groups during hypoxia.Conclusion: These data suggest that opioids acting on l-receptors in the rMR exert an excitatory modulation of hyperventilation induced by hypoxia.-
Formato: dc.format435-442-
Idioma: dc.languageen-
Publicador: dc.publisherWiley-Blackwell-
Relação: dc.relationActa Physiologica-
Relação: dc.relation5.930-
Relação: dc.relation1,542-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectControl of breathing-
Palavras-chave: dc.subjectopiates-
Palavras-chave: dc.subjectPulmonary ventilation-
Palavras-chave: dc.subjectraphe nuclei-
Título: dc.titleOpioid mu-receptors in the rostral medullary raphe modulate hypoxia-induced hyperpnea in unanesthetized rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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