Serotoninergic receptors in the anteroventral preoptic region modulate the hypoxic ventilatory response

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGargaglioni, Luciane H.-
Autor(es): dc.creatorBicego, Kenia C.-
Autor(es): dc.creatorNucci, Tatiane B.-
Autor(es): dc.creatorBranco, Luiz G. S.-
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Descrição: dc.descriptionHypothalamus is a site of integration of the hypoxic and thermal stimuli on breathing and there is evidence that serotonin (5-HT) receptors in the anteroventral preoptic region (AVPO) mediate hypoxic hypothermia. Once 5-HT is involved in the hypoxic ventilatory response (HVR), we investigated the participation of the 5-HT receptors (5-HT1, 5-HT2 and 5-HT7) in the AVPO in the HVR. To this end, pulmonary ventilation (V-E) of rats was measured before and after intra-AVPO microinjection of methysergide (a 5-HT1 and 5-HT2 receptor antagonist), WAY-100635 (a 5-HT1A receptor antagonist) and SB-269970 (a 5-HT7 receptor antagonist), followed by 60 min of hypoxia exposure (7% O-2). Intra-AVPO microinjection of vehicles or 5-HT antagonists did not change VE during normoxic conditions. Exposure of rats to 7% O-2 evoked typical hypoxia-induced hyperpnea after vehicle microinjection, which was not affected by methysergide. WAY-100635 and SB-269970 treatment caused an increased HVR, due to a higher tidal volume. Therefore, the current data provide the evidence that 5-HT acting on 5-HT1A and 5-HT7 receptors in the AVPO exert an inhibitory modulation on the HVR. (c) 2005 Elsevier B.V. All rights reserved.-
Formato: dc.format1-13-
Idioma: dc.languageen-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationRespiratory Physiology & Neurobiology-
Relação: dc.relation1.792-
Relação: dc.relation0,682-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectcontrol of breathing-
Palavras-chave: dc.subjectventilation-
Palavras-chave: dc.subjectHypoxia-
Palavras-chave: dc.subjectserotonin-
Palavras-chave: dc.subjectpreoptic area-
Palavras-chave: dc.subjectrats-
Palavras-chave: dc.subjecthypoxic ventilatory response-
Título: dc.titleSerotoninergic receptors in the anteroventral preoptic region modulate the hypoxic ventilatory response-
Tipo de arquivo: dc.typelivro digital-
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