The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorNorthwestern University (NU)-
Autor(es): dc.contributorSanta Casa Faculty of Medicine of São Paulo-
Autor(es): dc.contributorFeinberg School of Medicine-
Autor(es): dc.contributorSanta Casa Faculty of Medicine-
Autor(es): dc.creatorAzevedo, Vera Lucia Fernandes de-
Autor(es): dc.creatorSantos, Paulo Sergio Santana-
Autor(es): dc.creatorOliveira Jr, Gildàsio Silveira de-
Autor(es): dc.creatorMódolo, Gabriel Pinheiro-
Autor(es): dc.creatorDomingues, Maria Aparecida Custódio-
Autor(es): dc.creatorCastiglia, Yara Marcondes Machado-
Autor(es): dc.creatorVianna, Pedro Thadeu Galvão-
Autor(es): dc.creatorVane, Luiz Antonio-
Autor(es): dc.creatorMódolo, Norma Sueli Pinheiro-
Data de aceite: dc.date.accessioned2025-08-21T17:18:13Z-
Data de disponibilização: dc.date.available2025-08-21T17:18:13Z-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2014-05-20-
Data de envio: dc.date.issued2022-04-29-
Data de envio: dc.date.issued2013-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S0102-86502013000100002-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/250375-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/250375-
Descrição: dc.descriptionPURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSanta Casa Faculty of Medicine of São Paulo-
Descrição: dc.descriptionUNESP Botucatu Medical School Postgraduate Program in Anesthesiology-
Descrição: dc.descriptionNorthwestern University Feinberg School of Medicine Department of Anesthesiology-
Descrição: dc.descriptionUNESP Botucatu Medical School Department of Pathology-
Descrição: dc.descriptionPostgraduate Program in Anesthesiology Botucatu Medical School, UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Anesthesiology Northwestern University Feinberg School of Medicine, Chicago, IL-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School, UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Anesthesiology Botucatu Medical School, UNESP, Sao Paulo-
Descrição: dc.descriptionUNESP Botucatu Medical School Postgraduate Program in Anesthesiology-
Descrição: dc.descriptionUNESP Botucatu Medical School Department of Pathology-
Descrição: dc.descriptionUNESP Botucatu Medical School Department of Anesthesiology-
Descrição: dc.descriptionPostgraduate Program in Anesthesiology Botucatu Medical School, UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Pathology Botucatu Medical School, UNESP, Sao Paulo-
Descrição: dc.descriptionDepartment of Anesthesiology Botucatu Medical School, UNESP, Sao Paulo-
Descrição: dc.descriptionFAPESP: 10/08562-0-
Formato: dc.format05-09-
Formato: dc.formatapplication/pdf-
Idioma: dc.languageen-
Publicador: dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia-
Relação: dc.relationActa Cirúrgica Brasileira-
Relação: dc.relation0,395-
Direitos: dc.rightsinfo:eu-repo/semantics/openAccess-
???dc.source???: dc.sourceSciELO-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute kidney injury-
Palavras-chave: dc.subjectColloids-
Palavras-chave: dc.subjectFluid therapy-
Palavras-chave: dc.subjectHetastarch-
Palavras-chave: dc.subjectRats-
Título: dc.titleThe effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.