The Transcriptomic Landscape of Age-Induced Changes in Human Visceral Fat and the Predicted Omentum-Liver Connectome in Males

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidad de Antioquia (UdeA)-
Autor(es): dc.creatorMoraes, Diogo de-
Autor(es): dc.creatorMousovich-Neto, Felippe-
Autor(es): dc.creatorCury, Sarah Santiloni-
Autor(es): dc.creatorOliveira, Jakeline-
Autor(es): dc.creatorSouza, Jeferson dos Santos-
Autor(es): dc.creatorFreire, Paula Paccielli-
Autor(es): dc.creatorDal-Pai-Silva, Maeli-
Autor(es): dc.creatorMori, Marcelo Alves da Silva-
Autor(es): dc.creatorFernandez, Geysson Javier-
Autor(es): dc.creatorCarvalho, Robson Francisco-
Data de aceite: dc.date.accessioned2025-08-21T18:17:21Z-
Data de disponibilização: dc.date.available2025-08-21T18:17:21Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biomedicines11051446-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/250023-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/250023-
Descrição: dc.descriptionAging causes alterations in body composition. Specifically, visceral fat mass increases with age and is associated with age-related diseases. The pathogenic potential of visceral fat accumulation has been associated with its anatomical location and metabolic activity. Visceral fat may control systemic metabolism by secreting molecules that act in distal tissues, mainly the liver, through the portal vein. Currently, little is known about age-related changes in visceral fat in humans. Aiming to identify molecular and cellular changes occurring with aging in the visceral fat of humans, we analyzed publicly available transcriptomic data of 355 omentum samples from the Genotype-Tissue Expression portal (GTEx) of 20–79-year-old males and females. We identified the functional enrichment of genes associated with aging, inferred age-related changes in visceral fat cellularity by deconvolution analysis, profiled the senescence-associated secretory phenotype of visceral adipose tissue, and predicted the connectivity of the age-induced visceral fat secretome with the liver. We demonstrate that age induces alterations in visceral fat cellularity, synchronous to changes in metabolic pathways and a shift toward a pro-inflammatory secretory phenotype. Furthermore, our approach identified candidates such as ADIPOQ-ADIPOR1/ADIPOR2, FCN2-LPR1, and TF-TFR2 to mediate visceral fat-liver crosstalk in the context of aging. These findings cast light on how alterations in visceral fat with aging contribute to liver dysfunction and age-related disease etiology.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Sao Paulo State University UNESP, SP-
Descrição: dc.descriptionDepartment of Biochemistry and Tissue Biology University of Campinas, Monteiro Lobato St., 255, SP-
Descrição: dc.descriptionObesity and Comorbidities Research Center (OCRC) University of Campinas, SP-
Descrição: dc.descriptionExperimental Medicine Research Cluster (EMRC) University of Campinas, SP-
Descrição: dc.descriptionGrupo Biologia y Control de Enfermedades Infeciosas (BCEI) Facultad de Ciencias Exactas y Naturales Universidad de Antioquia (UdeA)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Sao Paulo State University UNESP, SP-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationBiomedicines-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectage-related diseases-
Palavras-chave: dc.subjectaging-
Palavras-chave: dc.subjectfat-liver crosstalk-
Palavras-chave: dc.subjectobesity-
Palavras-chave: dc.subjectvisceral adipose tissue-
Título: dc.titleThe Transcriptomic Landscape of Age-Induced Changes in Human Visceral Fat and the Predicted Omentum-Liver Connectome in Males-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.