Three-dimensional culture models: emerging platforms for screening the antitumoral efficacy of nanomedicines

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTofani, Larissa Bueno-
Autor(es): dc.creatorLuiz, Marcela Tavares-
Autor(es): dc.creatorPaes Dutra, Jessyca Aparecida-
Autor(es): dc.creatorAbriata, Juliana Palma-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T19:58:53Z-
Data de disponibilização: dc.date.available2025-08-21T19:58:53Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2217/nnm-2022-0205-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/250005-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/250005-
Descrição: dc.descriptionNanomedicines have been investigated for delivering drugs to tumors due to their ability to accumulate in the tumor tissues. 2D in vitro cell culture has been used to investigate the antitumoral potential of nanomedicines. However, a 2D model cannot adequately mimic the in vivo tissue conditions because of the lack of cell-cell interaction, a gradient of nutrients and the expression of genes. To overcome this limitation, 3D cell culture models have emerged as promising platforms that better replicate the complexity of native tumors. For this purpose, different techniques can be used to produce 3D models, including scaffold-free, scaffold-based and microfluidic-based models. This review addresses the principles, advantages and limitations of these culture methods for evaluating the antitumoral efficacy of nanomedicines.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSchool of Pharmaceutical Science of Ribeirao Preto University of Sao Paulo (USP)-
Descrição: dc.descriptionSchool of Pharmaceutical Science of Sao Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Pharmaceutical Science of Sao Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format633-647-
Idioma: dc.languageen-
Relação: dc.relationNanomedicine (London, England)-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcancer therapy-
Palavras-chave: dc.subjectdrug-delivery systems-
Palavras-chave: dc.subjectmulticellular spheroids-
Palavras-chave: dc.subjectscaffold-based model and microfluids devices-
Palavras-chave: dc.subjectscaffold-free model-
Título: dc.titleThree-dimensional culture models: emerging platforms for screening the antitumoral efficacy of nanomedicines-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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