Intranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's disease

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorPostgraduate in Pharmaceutical Sciences-
Autor(es): dc.contributorUniversity of Brasilia (UnB)-
Autor(es): dc.creatorFonseca-Santos, Bruno-
Autor(es): dc.creatorCazarin, Camila André-
Autor(es): dc.creatorda Silva, Patrícia Bento-
Autor(es): dc.creatordos Santos, Kaio Pini-
Autor(es): dc.creatorda Rocha, Márcia Cristina Oliveira-
Autor(es): dc.creatorBáo, Sônia Nair-
Autor(es): dc.creatorDe-Souza, Márcia Maria-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T19:40:26Z-
Data de disponibilização: dc.date.available2025-08-21T19:40:26Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.nano.2023.102689-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/250004-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/250004-
Descrição: dc.descriptionAlzheimer's disease (AD) is an illness that affects people aged 65 or older and affects around 6.5 million in the United States. Resveratrol is a chemical obtained from natural products and it exhibits biological activity based on inhibiting the formation, depolymerization of the amyloid, and decreasing neuroinflammation. Due to the insolubility of this compound; its incorporation in surfactant-based systems was proposed to design an intranasal formulation. A range of systems has been produced by mixing oleic acid, CETETH-20 and water. Polarised light microscopy (PLM), small angle x-ray scattering (SAXS) and transmission electron microscopy (TEM) confirm the initial liquid formulation (F) presented as microemulsion (ME). After dilution, the gelled systems were characterized as hexagonal mesophase and they showed feasibility proprieties. Pharmacological assays performed after intranasal administration showed the ability to improve learning and memory in animals, as well as remission of neuroinflammation via inhibition of interleukin.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences, São Paulo-
Descrição: dc.descriptionFederal University of Bahia (UFBA) Health Sciences Institute Department of Biotechnology, Bahia-
Descrição: dc.descriptionUniversity of Vale do Itajaí (UNIVALI) Postgraduate in Pharmaceutical Sciences, Santa Catarina-
Descrição: dc.descriptionDepartment of Genetics and Morphology Institute of Biological Sciences University of Brasilia (UnB), Federal District-
Descrição: dc.descriptionMicroscopy and Microanalysis Laboratory Department of Cell Biology Institute of Biological Sciences University of Brasilia (UnB), Federal District-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences, São Paulo-
Descrição: dc.descriptionFAPESP: 15/05394-2-
Descrição: dc.descriptionFAPESP: 2014/50928-2-
Descrição: dc.descriptionCNPq: 465687/2014-8-
Idioma: dc.languageen-
Relação: dc.relationNanomedicine: Nanotechnology, Biology, and Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBrain-
Palavras-chave: dc.subjectColloids-
Palavras-chave: dc.subjectMicroemulsion-
Palavras-chave: dc.subjectNeurological disease-
Palavras-chave: dc.subjectPolyoxyethylene (20) oleyl ether-
Título: dc.titleIntranasal in situ gelling liquid crystal for delivery of resveratrol ameliorates memory and neuroinflammation in Alzheimer's disease-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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