New Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect against Mycobacterium tuberculosis and Campylobacter jejuni

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Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorSilva, Raphael Tristão Cruvinel-
Autor(es): dc.creatorGuidotti-Takeuchi, Micaela-
Autor(es): dc.creatorPeixoto, Jéssica Laura Miranda-
Autor(es): dc.creatorDemarqui, Fernanda Manaia-
Autor(es): dc.creatorMori, Ananda Paula-
Autor(es): dc.creatorDumont, Carolyne Ferreira-
Autor(es): dc.creatorFerreira, Gabriella Rayane Aparecida-
Autor(es): dc.creatorPereira, Gabriele de Menezes-
Autor(es): dc.creatorRossi, Daise Aparecida-
Autor(es): dc.creatorCorbi, Pedro Paulo-
Autor(es): dc.creatorPavan, Fernando Rogério-
Autor(es): dc.creatorRezende Júnior, Celso de Oliveira-
Autor(es): dc.creatorMelo, Roberta Torres de-
Autor(es): dc.creatorGuerra, Wendell-
Data de aceite: dc.date.accessioned2025-08-21T17:48:04Z-
Data de disponibilização: dc.date.available2025-08-21T17:48:04Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules28093887-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249955-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249955-
Descrição: dc.descriptionThis work describes the preparation, characterization and antimicrobial activity of four palladium(II) complexes, namely, [Pd(meg)(1,10-phen)] 1, [Pd(meg)(PPh3)2] 2, [Pd(og)(1,10-phen)] 3 and [Pd(og)(PPh3)2] 4, where meg = methyl gallate, og = octyl gallate, 1,10-phen = 1,10-phenanthroline and PPh3 = triphenylphosphine. As to the chemical structures, spectral and physicochemical studies of 1–4 indicated that methyl or octyl gallate coordinates a palladium(II) ion through two oxygen atoms upon deprotonation. A chelating bidentate phenanthroline or two triphenylphosphine molecules complete the coordination sphere of palladium(II) ion, depending on the complex. The metal complexes were tested against the Mycobacterium tuberculosis H37Rv strain and 2 exhibited high activity (MIC = 3.28 μg/mL). As to the tests with Campylobacter jejuni, complex 1 showed a significant effect in reducing bacterial population (greater than 7 log CFU) in planktonic forms, as well as in the biomass intensity (IBF: 0.87) when compared to peracetic acid (IBF: 1.11) at a concentration of 400 μg/mL. The effect provided by these complexes has specificity according to the target microorganism and represent a promising alternative for the control of microorganisms of public health importance.-
Descrição: dc.descriptionInstitute of Chemistry Federal University of Uberlândia—UFU, Santa Mônica Campus, MG-
Descrição: dc.descriptionLaboratory of Experimental Molecular Epidemiology Federal University of Uberlândia—UFU, Umuarama Campus, MG-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences Paulista State University—UNESP, Araraquara Campus, SP-
Descrição: dc.descriptionInstitute of Chemistry State University of Campinas—UNICAMP, SP-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences Paulista State University—UNESP, Araraquara Campus, SP-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanti-infective drugs-
Palavras-chave: dc.subjectantibacterial activity-
Palavras-chave: dc.subjectCampylobacter jejuni-
Palavras-chave: dc.subjectMycobacterium tuberculosis-
Palavras-chave: dc.subjectpalladium(II) complexes-
Título: dc.titleNew Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect against Mycobacterium tuberculosis and Campylobacter jejuni-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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