Aloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTerasaki Institute for Biomedical Innovation (TIBI)-
Autor(es): dc.contributorCalifornia State University-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Caxias do Sul (UCS)-
Autor(es): dc.contributorPontificia Universidad Católica de Valparaíso-
Autor(es): dc.contributorThe University of Veterinary Medicine and Pharmacy in Košice-
Autor(es): dc.contributorReconstructive and Aesthetic Surgery University Hospital Ghent-
Autor(es): dc.contributorFederal University of Triangulo Mineiro (UFTM)-
Autor(es): dc.creatorHerculano, Rondinelli Donizetti-
Autor(es): dc.creatordos Santos, Thainá Oliveira-
Autor(es): dc.creatorde Barros, Natan Roberto-
Autor(es): dc.creatorPegorin Brasil, Giovana Sant'Ana-
Autor(es): dc.creatorScontri, Mateus-
Autor(es): dc.creatorCarvalho, Bruna Gregatti-
Autor(es): dc.creatorMecwan, Marvin-
Autor(es): dc.creatorFarhadi, Neda-
Autor(es): dc.creatorKawakita, Satoru-
Autor(es): dc.creatorPerego, Caio Humberto-
Autor(es): dc.creatorCarvalho, Flávio Alexandre-
Autor(es): dc.creatordos Santos, André Gonzaga-
Autor(es): dc.creatorGuerra, Nayrim Brizuela-
Autor(es): dc.creatorFloriano, Juliana Ferreira-
Autor(es): dc.creatorMussagy, Cassamo Ussemane-
Autor(es): dc.creatorTirpáková, Zuzana-
Autor(es): dc.creatorKhorsandi, Danial-
Autor(es): dc.creatorPeirsman, Arne-
Autor(es): dc.creatorNguyen, Huu Tuan-
Autor(es): dc.creatorGomez, Alejandro-
Autor(es): dc.creatorMandal, Kalpana-
Autor(es): dc.creatorde Mendonça, Ricardo José-
Autor(es): dc.creatorLi, Bingbing-
Autor(es): dc.creatorDokmeci, Mehmet Remzi-
Autor(es): dc.creatorJucaud, Vadim-
Data de aceite: dc.date.accessioned2025-08-21T21:24:06Z-
Data de disponibilização: dc.date.available2025-08-21T21:24:06Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2023.124779-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249937-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249937-
Descrição: dc.descriptionPsoriasis is a disease that causes keratinocytes to proliferate ten times faster than normal, resulting in chronic inflammation and immune cell infiltration in the skin. Aloe vera (A. vera) creams have been used topically for treating psoriasis because they contain several antioxidant species; however, they have several limitations. Natural rubber latex (NRL) has been used as occlusive dressings to promote wound healing by stimulating cell proliferation, neoangiogenesis, and extracellular matrix formation. In this work, we developed a new A. vera-releasing NRL dressing by a solvent casting method to load A. vera into NRL. FTIR and rheological analyzes revealed no covalent interactions between A. vera and NRL in the dressing. We observed that 58.8 % of the loaded A. vera, present on the surface and inside the dressing, was released after 4 days. Biocompatibility and hemocompatibility were validated in vitro using human dermal fibroblasts and sheep blood, respectively. We observed that ~70 % of the free antioxidant properties of A. vera were preserved, and the total phenolic content was 2.31-fold higher than NRL alone. In summary, we combined the antipsoriatic properties of A. vera with the healing activity of NRL to generate a novel occlusive dressing that may be indicated for the management and/or treatment of psoriasis symptoms simply and economically.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionTerasaki Institute for Biomedical Innovation (TIBI), 11507 W Olympic Blvd-
Descrição: dc.descriptionAutonomy Research Center for STEAHM (ARCS) California State University-
Descrição: dc.descriptionSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SP-
Descrição: dc.descriptionUniversity of Campinas (UNICAMP) Department of Materials and Bioprocesses Engineering School of Chemical Engineering, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Pharmacognosy Laboratory School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionArea of Exact Sciences and Engineering University of Caxias do Sul (UCS), RS-
Descrição: dc.descriptionEscuela de Agronomía Facultad de Ciencias Agronómicas y de los Alimentos Pontificia Universidad Católica de Valparaíso-
Descrição: dc.descriptionThe University of Veterinary Medicine and Pharmacy in Košice, Komenského-
Descrição: dc.descriptionPlastic Reconstructive and Aesthetic Surgery University Hospital Ghent-
Descrição: dc.descriptionDepartment of Biochemistry Pharmacology and Physiology Federal University of Triangulo Mineiro (UFTM), MG-
Descrição: dc.descriptionSão Paulo State University (UNESP) Bioengineering & Biomaterials Group School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Post-Graduate Program in Biotechnology Institute of Chemistry, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Pharmacognosy Laboratory School of Pharmaceutical Sciences, SP-
Descrição: dc.descriptionFAPESP: 2017/19603-8-
Descrição: dc.descriptionFAPESP: 2018/07342-8-
Descrição: dc.descriptionFAPESP: 2021/09207-3-
Descrição: dc.descriptionCNPq: 317203/2021-5-
Descrição: dc.descriptionCNPq: 401285/2022-7-
Descrição: dc.descriptionCNPq: 470261/2012-9-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAloe vera-
Palavras-chave: dc.subjectComplementary treatment-
Palavras-chave: dc.subjectNatural rubber latex-
Palavras-chave: dc.subjectOcclusive dressing-
Palavras-chave: dc.subjectPsoriasis-
Título: dc.titleAloe vera-loaded natural rubber latex dressing as a potential complementary treatment for psoriasis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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