Photo-responsive polymeric micelles for the light-triggered release of curcumin targeting antimicrobial activity

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorState University of Maringá-
Autor(es): dc.creatorTrigo-Gutierrez, Jeffersson Krishan-
Autor(es): dc.creatorCalori, Italo Rodrigo-
Autor(es): dc.creatorde Oliveira Bárbara, Geovana-
Autor(es): dc.creatorPavarina, Ana Claudia-
Autor(es): dc.creatorGonçalves, Renato Sonchini-
Autor(es): dc.creatorCaetano, Wilker-
Autor(es): dc.creatorTedesco, Antonio Claudio-
Autor(es): dc.creatorMima, Ewerton Garcia de Oliveira-
Data de aceite: dc.date.accessioned2025-08-21T21:22:13Z-
Data de disponibilização: dc.date.available2025-08-21T21:22:13Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fmicb.2023.1132781-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249931-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249931-
Descrição: dc.descriptionNanocarriers have been successfully used to solubilize, deliver, and increase the bioavailability of curcumin (CUR), but slow CUR release rates hinder its use as a topical photosensitizer in antimicrobial photodynamic therapy. A photo-responsive polymer (PRP) was designed for the light-triggered release of CUR with an effective light activation-dependent antimicrobial response. The characterization of the PRP was compared with non-responsive micelles comprising Pluronics™ P123 and F127. According to the findings, the PRP formed photo-responsive micelles in the nanometric scale (< 100 nm) with a lower critical micelle concentration (3.74 × 10−4 M−1, 5.8 × 10−4 M−1, and 7.2 × 10−6 M−1 for PRP, F127, P123, respectively, at 25°C) and higher entrapment efficiency of CUR (88.7, 77.2, and 72.3% for PRP, F127, and P123 micelles, respectively) than the pluronics evaluated. The PRP provided enhanced protection of CUR compared to P123 micelles, as demonstrated in fluorescence quenching studies. The light-triggered release of CUR from PRP occurred with UV light irradiation (at 355 nm and 25 mW cm−2) and a cumulative release of 88.34% of CUR within 1 h compared to 80% from pluronics after 36 h. In vitro studies showed that CUR-loaded PRP was non-toxic to mammal cell, showed inactivation of the pathogenic microorganisms Candida albicans, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus, and decreased biofilm biomass when associated with blue light (455 nm, 33.84 J/cm2). The findings show that the CUR-loaded PRP micelle is a viable option for antimicrobial activity.-
Descrição: dc.descriptionLaboratory of Applied Microbiology Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry Center of Nanotechnology and Tissue Engineering Photobiology and Photomedicine Research Group Faculty of Philosophy Sciences and Letters of Ribeirão Preto University of São Paulo, São Paulo-
Descrição: dc.descriptionDepartment of Chemistry Research Nucleus of Photodynamic Therapy State University of Maringá, Paraná-
Descrição: dc.descriptionLaboratory of Applied Microbiology Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbacteria-
Palavras-chave: dc.subjectfungi-
Palavras-chave: dc.subjectlight-
Palavras-chave: dc.subjectmicelles-
Palavras-chave: dc.subjectPhotochemotherapy-
Título: dc.titlePhoto-responsive polymeric micelles for the light-triggered release of curcumin targeting antimicrobial activity-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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