Higher expression of Th1/Th2-related cytokines in the intestine of Wistar rats with ligature-induced periodontitis

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Autor(es): dc.contributorGriffith University-
Autor(es): dc.contributorJames Cook University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorKarolinska Institutet-
Autor(es): dc.creatorde Mello-Neto, João Martins-
Autor(es): dc.creatorElangovan, Gayathiri-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorJohnson, Newell Walter-
Autor(es): dc.creatorGustafsson, Anders-
Autor(es): dc.creatorda Silva Figueredo, Carlos Marcelo-
Data de aceite: dc.date.accessioned2025-08-21T15:22:12Z-
Data de disponibilização: dc.date.available2025-08-21T15:22:12Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jre.13121-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249840-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249840-
Descrição: dc.descriptionObjective: This study aimed to investigate the impact of ligature-induced periodontitis (LIP) on histopathological and immunological outcomes in the colon of Wistar rats. Background: It has been repeatedly shown that inflammatory bowel disease (IBD) patients are at higher risk of developing periodontitis and presenting worse oral health than non-IBD patients. However, whether the chronic inflammatory process around teeth contributes to the pathophysiology of IBD needs to be further explored. Materials and Methods: Thirteen Wistar rats were allocated into LIP (n = 7) and controls (n = 6). Half of the colon was processed for histopathological analyses and immunohistochemical (CD45); the other half was homogenized for immunological analyses. Periodontal destruction was confirmed by measuring the distance from the cementum-enamel junction to the mandible's apical position of the mesial interproximal bone. The immunological analyses were performed with the Bio-Plex Th1/Th2 assay. Results: There was a significantly higher interproximal bone loss in LIP compared to controls. The LIP group showed a moderate infiltrate of inflammatory cells, predominantly mononucleated cells in the intestinal tissues. There was significantly higher expression of GM-CSF, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-10, IL-12 (p70), IL-13, and TNF-α in the intestinal tissues of LIP group compared to controls. Conclusion: Ligature-induced periodontitis was associated with an overexpression of Th1/Th2-related cytokines in the colon of Wistar rats.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionSchool of Medicine and Dentistry Griffith University-
Descrição: dc.descriptionCollege of Medicine and Dentistry James Cook University-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University-UNESP-
Descrição: dc.descriptionDivision of Oral Diseases Department of Dental Medicine Karolinska Institutet-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University-UNESP-
Formato: dc.format588-595-
Idioma: dc.languageen-
Relação: dc.relationJournal of Periodontal Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjectinflammatory bowel diseases-
Palavras-chave: dc.subjectintestine-
Palavras-chave: dc.subjectperiodontitis-
Palavras-chave: dc.subjectrats-
Título: dc.titleHigher expression of Th1/Th2-related cytokines in the intestine of Wistar rats with ligature-induced periodontitis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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