Integrative Analysis of the Ethanol Tolerance of Saccharomyces cerevisiae

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Groningen-
Autor(es): dc.contributorCiência e Tecnologia do Sudeste de Minas Gerais-
Autor(es): dc.contributorMax Planck Institute for Heart and Lung Research-
Autor(es): dc.creatorWolf, Ivan Rodrigo-
Autor(es): dc.creatorMarques, Lucas Farinazzo-
Autor(es): dc.creatorde Almeida, Lauana Fogaça-
Autor(es): dc.creatorLázari, Lucas Cardoso-
Autor(es): dc.creatorde Moraes, Leonardo Nazário-
Autor(es): dc.creatorCardoso, Luiz Henrique-
Autor(es): dc.creatorAlves, Camila Cristina de Oliveira-
Autor(es): dc.creatorNakajima, Rafael Takahiro-
Autor(es): dc.creatorSchnepper, Amanda Piveta-
Autor(es): dc.creatorGolim, Marjorie de Assis-
Autor(es): dc.creatorCataldi, Thais Regiani-
Autor(es): dc.creatorNijland, Jeroen G.-
Autor(es): dc.creatorPinto, Camila Moreira-
Autor(es): dc.creatorFioretto, Matheus Naia-
Autor(es): dc.creatorAlmeida, Rodrigo Oliveira-
Autor(es): dc.creatorDriessen, Arnold J. M.-
Autor(es): dc.creatorSimōes, Rafael Plana-
Autor(es): dc.creatorLabate, Mônica Veneziano-
Autor(es): dc.creatorGrotto, Rejane Maria Tommasini-
Autor(es): dc.creatorLabate, Carlos Alberto-
Autor(es): dc.creatorFernandes Junior, Ary-
Autor(es): dc.creatorJustulin, Luis Antonio-
Autor(es): dc.creatorCoan, Rafael Luiz Buogo-
Autor(es): dc.creatorRamos, Érica-
Autor(es): dc.creatorFurtado, Fabiana Barcelos-
Autor(es): dc.creatorMartins, Cesar-
Autor(es): dc.creatorValente, Guilherme Targino-
Data de aceite: dc.date.accessioned2025-08-21T19:56:31Z-
Data de disponibilização: dc.date.available2025-08-21T19:56:31Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms24065646-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249837-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249837-
Descrição: dc.descriptionEthanol (EtOH) alters many cellular processes in yeast. An integrated view of different EtOH-tolerant phenotypes and their long noncoding RNAs (lncRNAs) is not yet available. Here, large-scale data integration showed the core EtOH-responsive pathways, lncRNAs, and triggers of higher (HT) and lower (LT) EtOH-tolerant phenotypes. LncRNAs act in a strain-specific manner in the EtOH stress response. Network and omics analyses revealed that cells prepare for stress relief by favoring activation of life-essential systems. Therefore, longevity, peroxisomal, energy, lipid, and RNA/protein metabolisms are the core processes that drive EtOH tolerance. By integrating omics, network analysis, and several other experiments, we showed how the HT and LT phenotypes may arise: (1) the divergence occurs after cell signaling reaches the longevity and peroxisomal pathways, with CTA1 and ROS playing key roles; (2) signals reaching essential ribosomal and RNA pathways via SUI2 enhance the divergence; (3) specific lipid metabolism pathways also act on phenotype-specific profiles; (4) HTs take greater advantage of degradation and membraneless structures to cope with EtOH stress; and (5) our EtOH stress-buffering model suggests that diauxic shift drives EtOH buffering through an energy burst, mainly in HTs. Finally, critical genes, pathways, and the first models including lncRNAs to describe nuances of EtOH tolerance are reported here.-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology School of Agriculture São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Applied Biotechnology Clinical Hospital of the Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Parasitology Biomedical Sciences Institute University of São Paulo (USP)-
Descrição: dc.descriptionLaboratório Max Feffer de Genética de Plantas Escola Superior de Agricultura Luiz de Queiroz Universidade de São Paulo (USP)-
Descrição: dc.descriptionMolecular Microbiology Groningen Biomolecular Sciences and Biotechnology Institute University of Groningen, Nijenborgh 7-
Descrição: dc.descriptionZernike Institute for Advanced Materials University of Groningen, Nijenborgh 7-
Descrição: dc.descriptionInstituto Federal de Educação Ciência e Tecnologia do Sudeste de Minas Gerais, Campus Muriaé-
Descrição: dc.descriptionLaboratory of Bacteriology Department of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionMax Planck Institute for Heart and Lung Research-
Descrição: dc.descriptionDepartment of Bioprocess and Biotechnology School of Agriculture São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Applied Biotechnology Clinical Hospital of the Medical School São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Bacteriology Department of Chemical and Biological Sciences Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionUniversidade Estadual Paulista: 12/2015-PROPe-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCRISPR–Cas9-
Palavras-chave: dc.subjectdata integration-
Palavras-chave: dc.subjectlncRNAs-
Palavras-chave: dc.subjectlncRNA–protein interactions-
Palavras-chave: dc.subjectmembraneless organelles-
Palavras-chave: dc.subjectomics-
Palavras-chave: dc.subjectsystems biology-
Título: dc.titleIntegrative Analysis of the Ethanol Tolerance of Saccharomyces cerevisiae-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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