Antifungal Action of Herbal Plants’ Glycolic Extracts against Candida Species

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMeccatti, Vanessa Marques-
Autor(es): dc.creatorSantos, Lana Ferreira-
Autor(es): dc.creatorde Carvalho, Lara Steffany-
Autor(es): dc.creatorSouza, Clara Bulhões-
Autor(es): dc.creatorCarvalho, Cláudio Antonio Talge-
Autor(es): dc.creatorMarcucci, Maria Cristina-
Autor(es): dc.creatorAbu Hasna, Amjad-
Autor(es): dc.creatorde Oliveira, Luciane Dias-
Data de aceite: dc.date.accessioned2025-08-21T17:07:13Z-
Data de disponibilização: dc.date.available2025-08-21T17:07:13Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/molecules28062857-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249823-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249823-
Descrição: dc.descriptionCandida spp. cause fungal infection that affects patients’ oral health. This study aimed to evaluate the isolated and synergistic antifungal effect of Rosa centifolia L., Curcuma longa L., Rosmarinus officinalis L., and Punica granatum L. glycolic extracts against Candida albicans, Candida dubliniensis, Candida tropicalis, and Candida krusei planktonic and biofilm forms. The plant extracts were chemically characterized and the main compounds were quantified by high-performance liquid chromatography (HPLC-DAD) analysis. The minimum inhibitory and minimum fungicidal concentrations of the extracts were determined, and antibiofilm activity was evaluated by MTT assay. Data were analyzed by one-way ANOVA and Tukey’s tests, and by Kruskal–Wallis and Dunn’s tests, considering a significance level of 5%. The main compounds identified in each of the extracts were: p-coumaric acid (2153.22 μg/100 mL) in the rosemary extract, gallotannins (4318.31 μg/100 mL) in the pomegranate extract, quercetin derivatives (3316.50 μg/100 mL) in the extract of white roses, and curcumin (135.09 μg/100 mL) in the turmeric extract. The combination of R. centifolia and C. longa glycolic extracts was effective against C. albicans, C. dubliniensis, and C. tropicalis biofilms over different periods (p < 0.05). The combination of R. officinalis and P. granatum glycolic extracts was effective against C. albicans and C. krusei biofilms after 30 min, and against C. tropicalis after 24 h, with all combinations showing an average reduction of 50% in cell viability (p < 0.05). In conclusion, the combined plant extracts have antifungal and antibiofilm action against Candida spp. in different concentrations and times of action.-
Descrição: dc.descriptionScientific Research and Technology Development Program of Guangxi-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (ICT-UNESP), SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP), SP-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (ICT-UNESP), SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP), SP-
Descrição: dc.descriptionScientific Research and Technology Development Program of Guangxi: 5344-
Idioma: dc.languageen-
Relação: dc.relationMolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectCandida dubliniensis-
Palavras-chave: dc.subjectCandida krusei-
Palavras-chave: dc.subjectCandida tropicalis-
Palavras-chave: dc.subjectCurcuma longa-
Palavras-chave: dc.subjectPunica granatum-
Palavras-chave: dc.subjectRosa centifolia-
Palavras-chave: dc.subjectRosmarinus-
Título: dc.titleAntifungal Action of Herbal Plants’ Glycolic Extracts against Candida Species-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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