Behind Base J: The Roles of JBP1 and JBP2 on Trypanosomatids

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorAssis, Luiz Henrique de Castro-
Autor(es): dc.creatorde Paiva, Stephany Cacete-
Autor(es): dc.creatorCano, Maria Isabel Nogueira-
Data de aceite: dc.date.accessioned2025-08-21T23:42:23Z-
Data de disponibilização: dc.date.available2025-08-21T23:42:23Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pathogens12030467-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249813-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249813-
Descrição: dc.descriptionβ-D-glucopyranosyloxymethiluracil (Base J) is a modified thymidine base found in kinetoplastids and some related organisms. Interestingly, Base J distribution into the genome can vary depending on the organism and its life stage. Base J is reported to be found mostly at telomeric repeats, on inactive variant surface glycoproteins (VSG’s) expression sites (e.g., T. brucei), in RNA polymerase II termination sites and sub-telomeric regions (e.g., Leishmania). This hypermodified nucleotide is synthesized in two steps with the participation of two distinct thymidine hydroxylases, J-binding protein 1 and 2 (JBP1 and JBP2, respectively) and a β-glucosyl transferase. A third J-binding protein, named JBP3, was recently identified as part of a multimeric complex. Although its structural similarities with JBP1, it seems not to be involved in J biosynthesis but to play roles in gene expression regulation in trypanosomatids. Over the years, with the characterization of JBP1 and JBP2 mutant lines, Base J functions have been targeted and shone a light on that matter, showing genus-specific features. This review aims to explore Base J’s reported participation as a regulator of RNA polymerase II transcription termination and to summarize the functional and structural characteristics and similarities of the remarkable JBP proteins in pathogenic trypanosomatids.-
Descrição: dc.descriptionTelomeres Laboratory Department of Chemical and Biological Sciences Biosciences Institute São Paulo State University (UNESP), SP-
Descrição: dc.descriptionTelomeres Laboratory Department of Chemical and Biological Sciences Biosciences Institute São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationPathogens-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBase J-
Palavras-chave: dc.subjectJ-binding proteins-
Palavras-chave: dc.subjecttrypanosomatids-
Título: dc.titleBehind Base J: The Roles of JBP1 and JBP2 on Trypanosomatids-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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