Lyotropic liquid crystal mesophases as transdermal delivery systems for lipophilic drugs: A comparative study

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Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.contributorFederal University of Paraíba-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Vale do São Francisco-
Autor(es): dc.creatorde Araujo, Guilherme Rodolfo Souza-
Autor(es): dc.creatorAzevedo Lima, Odeanny Vitória-
Autor(es): dc.creatorBarreto Neujahr, João Pedro-
Autor(es): dc.creatorMatos, Saulo Santos-
Autor(es): dc.creatorde Souza, Thalisson Amorim-
Autor(es): dc.creatordos Santos, Aline Martins-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorde Souza Araujo, Adriano Antunes-
Autor(es): dc.creatorDuarte, Marcelo Cavalcante-
Autor(es): dc.creatorda Cunha Gonsalves, Joyce Kelly Marinheiro-
Autor(es): dc.creatorde Souza Nunes, Rogéria-
Autor(es): dc.creatordos Santos, Marcio Roberto Viana-
Autor(es): dc.creatorVitorino Sarmento, Victor Hugo-
Autor(es): dc.creatorMoreira Lira, Ana Amélia-
Data de aceite: dc.date.accessioned2025-08-21T17:23:12Z-
Data de disponibilização: dc.date.available2025-08-21T17:23:12Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-05-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2023.122853-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249780-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249780-
Descrição: dc.descriptionThe present work aimed to evaluate different Liquid Crystal Mesophases (LCM) as transdermal drug delivery systems (TDDS) for nifedipine (NFD), a lipophilic drug model. The formulations composed of water, Citrus sinensis essential oil (CSEO), PPG-5-CETETH-20, and Olive oil ester PEG-7 were obtained and characterized by polarized light microscopy (PLM), rheology, small-angle x-ray scattering (SAXS), Fourier transform infrared coupled with an attenuated total reflection accessory (FTIR-ATR) and in vitro assays: bioadhesion, drug release, skin permeation, and retention tests. As a result, changes in component proportions led to several transparent viscous systems with an anisotropic profile. PLM and SAXS proved the presence of lamellar (S1), hexagonal (S3), and lamellar + hexagonal (S2) LCM, and rheology showed a high viscoelasticity profile. LCMs were able to adhere to the skin, and S2 achieved higher adhesion strength. NFD (5 mg/mL) has not modified the organization of LCMs. Results also showed that S3 promoted higher permeation and retention and higher disorganization of stratum corneum lipids, which is the main permeation-enhancing mechanism. Thus, the formulations obtained can carry and improve drug delivery through the skin and are promising TDDS for lipophilic drug administration, such as NFD.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Pharmacy Federal University of Sergipe, SE-
Descrição: dc.descriptionInstitute for Research in Pharmaceutical and Medications Federal University of Paraíba, PB-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences Paulista State University, SP-
Descrição: dc.descriptionPharmacy Collegiate Federal University of Vale do São Francisco, PE-
Descrição: dc.descriptionDepartment of Physiology Federal University of Sergipe, SE-
Descrição: dc.descriptionDepartment of Chemistry Federal University of Sergipe, SE-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences Paulista State University, SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Pharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectLyotropic liquid crystal-
Palavras-chave: dc.subjectNanostructured system-
Palavras-chave: dc.subjectPharmaceutical nanotechnology-
Palavras-chave: dc.subjectTransdermal drug delivery system-
Título: dc.titleLyotropic liquid crystal mesophases as transdermal delivery systems for lipophilic drugs: A comparative study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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