Safety of beta-alanine supplementation in humans: a narrative review

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorManchester Metropolitan University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Oliveira, Erick P.-
Autor(es): dc.creatorArtioli, Guilherme G.-
Autor(es): dc.creatorBurini, Roberto Carlos-
Data de aceite: dc.date.accessioned2025-08-21T16:40:28Z-
Data de disponibilização: dc.date.available2025-08-21T16:40:28Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11332-023-01052-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249669-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249669-
Descrição: dc.descriptionCarnosine levels play a significant role in intracellular pH buffering during exercise. The limiting factor for muscle carnosine synthesis is the availability of β-alanine. Results from meta-analysis showed a significant positive effect of β-alanine supplementation on high-intensity exercise performance. Nonetheless, much less has been described about the safety of β-alanine. The available literature indicates no adverse events related to β-alanine usage; side effects such as paresthesia may be observed if a large single high dose of β-alanine is taken, but the symptom can be attenuated either by using splitting doses (< 1.6 g) or a sustained-release formula. No adverse effects have been reported up to 24 weeks of β-alanine supplementation (3.2 g.day−1), but the adverse effects of longer supplementation periods are still unknown. Most of the existing clinical studies were not designed with safety evaluations as primary end points. β-Alanine is currently considered to be safe in healthy populations, at recommended doses, by the International Society of Sports Nutrition stands position, while the Australian Institute of Sports has established β-alanine as a safe performance-enhancing supplement with strong scientific evidence (grade A). Cohort studies are needed evaluating the safety of β-alanine among representative populations, and the effects of co-variables such as sex, age, and ethnicity.-
Descrição: dc.descriptionLaboratory of Nutrition Exercise and Health (LaNES) School of Medicine Federal University of Uberlandia, Av. Para, 1.720 Bloco 2U, Sala 20, Campus Umuarama, MG-
Descrição: dc.descriptionDepartment of Life Sciences Manchester Metropolitan University, John Dalton Building-
Descrição: dc.descriptionSao Paulo State University (UNESP)-
Descrição: dc.descriptionSao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationSport Sciences for Health-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdverse events-
Palavras-chave: dc.subjectExercise-
Palavras-chave: dc.subjectPerformance-
Palavras-chave: dc.subjectSafety-
Palavras-chave: dc.subjectSide effects-
Título: dc.titleSafety of beta-alanine supplementation in humans: a narrative review-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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