Pleiotropic Effects of Nitric Oxide on SARS-CoV-2 Infections

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUnion of the College of the Great Lakes (UNILAGO)-
Autor(es): dc.creatorTerroni, Barbara-
Autor(es): dc.creatorLopes, Juliana Romano-
Autor(es): dc.creatorChin, Chung Man-
Autor(es): dc.creatorDos Santos, Jean Leandro-
Data de aceite: dc.date.accessioned2025-08-21T22:43:57Z-
Data de disponibilização: dc.date.available2025-08-21T22:43:57Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/2666796701999201230121515-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249656-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249656-
Descrição: dc.descriptionInfection by β-coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coron-avirus-2) alters the homeostasis of the vascular endothelium, promoting an inflammatory state which causes damage and favors the prothrombotic state. The direct viral cytotoxicity induced by the SARS-CoV-2 leads to endothelial cell death; thus, altering the vessel functions. Moreover, SARS-CoV infection induces endothelial dysfunction (ED) and reduces the levels of nitric oxide (NO); thus, aggravating the vascular injuries, which promotes thrombotic events due to an altera-tion in the homeostasis. NO is a pleiotropic molecule that induces vasodilation, regulates the immune response, inhibits platelet aggregation, and decreases the cellular adhesion to vascular en-dothelium. Moreover, NO acts directly against invasive agents, exhibiting antibacterial, antiviral, and antifungal activity. High levels of NO result in an increase in the ED, causing an inflammatory amplification that aggravates the disease through undesirable positive feedback. The objective of this review was to present and discuss the involvement of NO on ED in SARS-CoV-2 infections. This review may also highlight new perspectives for therapeutic interventions through the supple-mentation of exogenous NO. The maintenance of homeostatic NO levels could represent a useful approach in the prevention of coronavirus-induced ED.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences, São Paulo-
Descrição: dc.descriptionAdvanced Research Center in Medicine School of Medicine Union of the College of the Great Lakes (UNILAGO), São Paulo-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Sciences, São Paulo-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2018/11079-0-
Descrição: dc.descriptionCNPq: 304731/2017-0-
Descrição: dc.descriptionCNPq: 313435/2019-7-
Idioma: dc.languageen-
Relação: dc.relationCoronaviruses-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectendothelium dysfunction-
Palavras-chave: dc.subjectinhaled NO-
Palavras-chave: dc.subjectnitric oxide-
Palavras-chave: dc.subjectNO donors-
Palavras-chave: dc.subjectSARS-COV-2-
Título: dc.titlePleiotropic Effects of Nitric Oxide on SARS-CoV-2 Infections-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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