Effect of Photobiomodulation Therapy Associated With Biphasic Phosphate Calcium on Bone Repair: A Histomorphometric Study in Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFaculdade Santo Antônio-
Autor(es): dc.creatorDe Marco, Andréa Carvalho-
Autor(es): dc.creatorTorquato, Letícia Cavassini-
Autor(es): dc.creatorRibeiro, Tatiana Camacho-
Autor(es): dc.creatorNunes, Camilla Moretto-
Autor(es): dc.creatorBernardo, Daniella Vicensotto-
Autor(es): dc.creatorMaciel, Clarissa Carvalho Martins-
Autor(es): dc.creatorPereira, Kauê Alberto-
Autor(es): dc.creatorJardini, Maria Aparecida Neves-
Autor(es): dc.creatorSantamaria, Mauro Pedrine-
Data de aceite: dc.date.accessioned2025-08-21T21:09:49Z-
Data de disponibilização: dc.date.available2025-08-21T21:09:49Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.34172/jlms.2022.33-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249643-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249643-
Descrição: dc.descriptionIntroduction: This study aimed to investigate the effects of photobiomodulation (PBM) therapy associated with biphasic calcium phosphate on calvaria critical defects in rats. Methods: Forty-eight (90 days old) adult male rats (Rattus norvegicus, Albinus variation, Wistar) received critical defects of 5 mm in diameter, which were made on their skull, and they were randomly assigned into the following groups: C-blood clot, B-biphasic calcium phosphate, L-photobiomodulation therapy, and B + L-biphasic calcium phosphate + photobiomodulation therapy. A low-level a gallium aluminum arsenide (GaAlAs) laser was applied in a single dose during surgery, in a wavelength of 660 nm and total energy density of 45 J/cm2. On 30th and 60th days, the animals from each group were euthanized. Histological and histomorphometric analyses were performed. Results: In 30 days, almost all specimens (C, L, B and B + L) showed bone neoformation areas in regions near the borders of the surgical defect. In 60 days, in many specimens (C, L, B, B + L), it was possible to see a narrow neoformed bone structure along almost the whole extension of the surgical defect, though it was thinner than the original calvary bone. Data were recorded as mean ± standard deviation, and after normality was tested, a suitable statistical test was applied (α = 5%). On day 60, there was a statistically significant difference when comparing the proportion of neoformation area between group L (0.52% ± 0.13) and group B + L (0.20% ± 0.08). Group L showed a difference compared with all the groups when we compared the remaining distance between the edges of neoformed bone (C × L, P = 0.0431; B × L, P = 0.0386; L × B + L, P = 0.0352), demonstrating a great defect closure. Conclusion: Our findings suggest that although biphasic calcium phosphate exerts some osteogenic activity during bone repair, PBM therapy is not able to modulate this process-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery – Division of Periodontology Sao Paulo State University (UNESP) Institute of Science and Technology-
Descrição: dc.descriptionDivision of Periodontology Pre-clinical Faculdade Santo Antônio-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery – Division of Periodontology Sao Paulo State University (UNESP) Institute of Science and Technology-
Descrição: dc.descriptionFAPESP: 2015/09614-7-
Idioma: dc.languageen-
Relação: dc.relationJournal of Lasers in Medical Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiocompatible materials-
Palavras-chave: dc.subjectBone regeneration-
Palavras-chave: dc.subjectBone substitutes-
Palavras-chave: dc.subjectLaser therapy-
Palavras-chave: dc.subjectRats-
Título: dc.titleEffect of Photobiomodulation Therapy Associated With Biphasic Phosphate Calcium on Bone Repair: A Histomorphometric Study in Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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