Prenatal exposure to sertraline, associated or not with stress, can negatively program somatic and neurobehavioral development of female rats, and dysregulate reproductive function in adulthood

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMoura, Mayara Silva-
Autor(es): dc.creatorLozano, Ana Flávia Quiarato-
Autor(es): dc.creatorTavares, Bruna Marques-
Autor(es): dc.creatorFigueiredo, Thamíris Moreira-
Autor(es): dc.creatorFranco de Barros, Jorge Willian-
Autor(es): dc.creatorValencise, Lethicia-
Autor(es): dc.creatorde Grava Kempinas, Wilma-
Data de aceite: dc.date.accessioned2025-08-21T16:41:12Z-
Data de disponibilização: dc.date.available2025-08-21T16:41:12Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2023.108336-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249604-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249604-
Descrição: dc.descriptionSelective serotonin reuptake inhibitors (SSRIs) are prescribed to pregnant women for treating mental illnesses. Among the drugs of this class, sertraline (ST) is the antidepressant therapy recommended most frequently. Therefore, this study aimed to evaluate the impact of gestational ST treatment on reproductive parameters and toxicological target organs of rat female offspring, as well as on somatic, reflex and neurobehavioral development, in a model of maternal adversity. Pregnant Wistar rats received vehicle (filtered water) or ST hydrochloride (20 mg/Kg/day diluted in vehicle) by oral gavage, associated or not with restraint stress for 1 h/day from gestational days 13–20. F1 female offspring was evaluated on reproductive parameters, body weight and somatic and reflex milestones from postnatal day (PND) 1. On PNDs 25 and 72, the elevated-plus-maze test was performed, while toxicological target organs were evaluated on PNDs 42 and 80. In utero exposure to ST, regardless of exposure to stress, reduced body weight at birth and affected the somatic development and estrous cycle. The absolute and relative thyroid weights were increased in Stress/ST group during puberty and adulthood, while the percentage of ovarian structures and the absolute uterine weight were altered in this group on PND 80. Prenatal exposure only to ST reduced initial body weight gain, delayed fur development and increased anxiety-like behavior on PND 25. Thus, this experimental study suggests that intrauterine exposure to ST disrupts the fetal environment and can negatively program serotonin-regulated processes. Furthermore, it impacts thyroid weight when associated with stress.-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionGraduate Program in General and Applied Biology São Paulo State University (UNESP) Institute of Biosciences, SP-
Descrição: dc.descriptionLaboratory of Reproductive and Developmental Biology and Toxicology Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionGraduate Program in General and Applied Biology São Paulo State University (UNESP) Institute of Biosciences, SP-
Descrição: dc.descriptionLaboratory of Reproductive and Developmental Biology and Toxicology Department of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCNPq: 312118/2017-1-
Idioma: dc.languageen-
Relação: dc.relationReproductive Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFetal programming-
Palavras-chave: dc.subjectNeurodevelopment-
Palavras-chave: dc.subjectPrenatal stress-
Palavras-chave: dc.subjectReproductive toxicology-
Palavras-chave: dc.subjectSertraline-
Título: dc.titlePrenatal exposure to sertraline, associated or not with stress, can negatively program somatic and neurobehavioral development of female rats, and dysregulate reproductive function in adulthood-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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