The Mongolian Gerbil as a Useful Experimental Model in Reproductive Biology

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorFederal University of Jataí-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorRuiz, Thalles Fernando Rocha-
Autor(es): dc.creatorVilamaior, Patricia Simone Leite-
Autor(es): dc.creatorGrigio, Vitor-
Autor(es): dc.creatorColleta, Simone Jacovaci-
Autor(es): dc.creatorZucão, Mariele Ilario-
Autor(es): dc.creatorde Campos, Silvana Gisele Pegorin-
Autor(es): dc.creatordos Santos, Fernanda Cristina Alcântara-
Autor(es): dc.creatorBiancardi, Manoel Francisco-
Autor(es): dc.creatorPerez, Ana Paula Silva-
Autor(es): dc.creatorTaboga, Sebastião Roberto-
Autor(es): dc.creatorLeonel, Ellen Cristina Rivas-
Data de aceite: dc.date.accessioned2025-08-21T20:04:12Z-
Data de disponibilização: dc.date.available2025-08-21T20:04:12Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s43032-023-01171-6-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249600-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249600-
Descrição: dc.descriptionUltimately, the Mongolian gerbils (Meriones unguiculatus) have acquired a relevant role in biological and biomedical experiments alongside other rodents. The use of gerbils in research has been mainly oriented to physiological and pharmacological studies, with special attention to nervous, digestive, and auditory systems as well as microbiology and parasitology. Ultimately, gerbils have also been applied for studying carcinogenesis in different organs and systems, since these animals show a natural propensity to develop spontaneous proliferative lesions, especially in steroid-responsive organs. This characteristic shed light on the reproductive aspects of this rodent model regarding morphological features in male and female individuals. This review of literature summarizes the significance of this model as an alternative to the use of inbred mice and rats in reproductive experimental research, highlighting recent findings. Gerbils have contributed to the expansion of knowledge in prostate biology in male and female individuals, providing studies related to prostatic morphogenesis and neoplasia. In the testes, spermiogenesis occurs in 15 steps, differently from other experimental models. Also, the complete maturation of the testis-epididymal complex occurs between the second and third months. Mammary gland alterations related to the estrous cycle and pregnancy were described, as well as its modulation under endogenous and exogenous estrogenic compounds. The ovaries frequently present ovarian cysts. Furthermore, this organ shows predominantly interstitial steroidogenic glands in the stroma, especially at aging. Adrenal gland shows a large size compared to other animals, presenting three distinct zones with a remarkable role in steroidogenesis.-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University, Rua Cristóvão Colombo, 2265 Jardim Nazareth, SP-
Descrição: dc.descriptionDepartment of Histology Embryology and Cell Biology Institute of Biological Sciences Federal University of Goiás, Avenida Esperança, S/N, Câmpus Samambaia, Goiás-
Descrição: dc.descriptionAcademic Unit of Health Sciences Medicine Course Federal University of Jataí, BR 36, Km 195, Goiás-
Descrição: dc.descriptionInstitute of Biology University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University, Rua Cristóvão Colombo, 2265 Jardim Nazareth, SP-
Idioma: dc.languageen-
Relação: dc.relationReproductive Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAnimal experimentation-
Palavras-chave: dc.subjectMorphology-
Palavras-chave: dc.subjectReproduction-
Palavras-chave: dc.subjectRodent-
Título: dc.titleThe Mongolian Gerbil as a Useful Experimental Model in Reproductive Biology-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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