Hydroxymethylnitrofurazone (NFOH) decreases parasitaemia, parasitism and tissue lesion caused by infection with the Bolivia Trypanosoma cruzi type I strain in Swiss and C57BL/6 mice

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorScarim, Cauê Benito-
Autor(es): dc.creatorde Andrade, Cleverton Roberto-
Autor(es): dc.creatorFalcone, Rossana-
Autor(es): dc.creatorAmbrozini, Letícia Moreno-
Autor(es): dc.creatorSenhorelli, Vitor Izidoro-
Autor(es): dc.creatorda Rosa, João Aristeu-
Autor(es): dc.creatorChin, Chung Man-
Data de aceite: dc.date.accessioned2025-08-21T18:49:11Z-
Data de disponibilização: dc.date.available2025-08-21T18:49:11Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s2175-97902022e20277-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249542-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249542-
Descrição: dc.descriptionThe chemical hydroxymethylation of the antimicrobial nitrofurazone leads to the prodrug NFOH, also increases the anti-T. cruzi activities (in vitro and in vivo), as well as showed non-genotoxic (Ames and micronucleus assays). In the present study, we assessed the anti-T. cruzi effect of the NFOH In vivo-in acute Swiss and C57Bl/6 experimental Chagas models. The treatment started at 5 days post-infection during 20 consecutive days (orally, once day, 150mg/kg), and the parasitaemia as well as histopathology analysis were performed. In both experimental murine models, NFOH was able to reduce parasitemia blood avoiding parasitic reactivation, during immunosuppression period (dexamethasone 5mg/kg, 14 days), in 100% of the mice, and decrease tissue parasite nests, demonstrating absence of amastigote forms in all organs (100%) analyzed, data similar to benznidazole (BZN). Therefore, the results shown here pointing to the NFOH as promising compound for further preclinical studies, being a high potential drug to effective and safe chemotherapy to Chagas disease.-
Descrição: dc.descriptionSao Paulo State University “Júlio de Mesquita Filho” UNESP Faculty of Pharmaceutical Sciences Department of Pharmaceuticals and Medicines, SP-
Descrição: dc.descriptionSao Paulo State University “Júlio de Mesquita Filho” UNESP Faculty of Pharmaceutical Sciences Department of Pharmaceuticals and Medicines, SP-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Pharmaceutical Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute stage-
Palavras-chave: dc.subjectBenznidazole (BZN)-
Palavras-chave: dc.subjectBolivia strain-
Palavras-chave: dc.subjectChagas disease-
Palavras-chave: dc.subjectHydroxymethylnitrofurazone (NFOH)-
Palavras-chave: dc.subjectTrypanosoma cruzi-
Título: dc.titleHydroxymethylnitrofurazone (NFOH) decreases parasitaemia, parasitism and tissue lesion caused by infection with the Bolivia Trypanosoma cruzi type I strain in Swiss and C57BL/6 mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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