Antinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFaculty of Health Sciences-
Autor(es): dc.contributorUnigran Capital University Center-
Autor(es): dc.contributorFederal University of Mato Grosso Do Sul-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAnhanguera-Uniderp University-
Autor(es): dc.contributorState University of Mato Grosso do Sul-
Autor(es): dc.creatorMatos Leitão, Maicon-
Autor(es): dc.creatorEuclides Silva-Filho, Saulo-
Autor(es): dc.creatorArena, Arielle Cristina-
Autor(es): dc.creatorHeredia-Vieira, Silvia Cristina-
Autor(es): dc.creatorCardoso, Cláudia Andrea Lima-
Autor(es): dc.creatorKassuya, Cândida Aparecida Leite-
Data de aceite: dc.date.accessioned2025-08-21T21:33:48Z-
Data de disponibilização: dc.date.available2025-08-21T21:33:48Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jep.2022.116018-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249515-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249515-
Descrição: dc.descriptionEthnopharmacological relevance: Serjania marginata Casar (Sapindaceae Family) Leaves are popularly used against abdominal pain. Antiulcer properties of S. marginata were scientifically described, however rare studies showed the antinociceptive effects of this plant. Aim of study: In this study, we investigated the antinociceptive and anti-inflammatory effects of aqueous extract obtained from Serjania marginata leaves (AESM) in nociception/inflammation models. Material and methods: AESM was analyzed in FIA-ESI-IT-MS and Mass spectrometer LTQ XL. AESM oral administration (p.o.) (30, 100 and 300 mg/kg), dexamethasone subcutaneous injection (1 mg/kg, s.c.) and morphine (5 mg/kg, s.c.) were tested against the acetic acid-induced nociception, carrageenan-induced acute inflammatory paw edema/hyperalgesia, formalin-induced nociception and carrageenan-induced pleurisy in Swiss mice. Results: Flavonoids rutin was detected in the phytochemical analysis of this extract. Oral treatment of AESM 300 mg/kg significantly reduced the number of acetic acid-induced abdominal writhing. AESM (100 and 300 mg/kg) significantly inhibited formalin-induced nociception, mechanical hyperalgesia and paw edema in carrageenan-model. Furthermore, AESM significantly inhibited leukocyte migration and protein exudation in the carrageenan-induced pleurisy test. Conclusion: This study confirms the antinociceptive, and anti-inflammatory activity of AESM, which may explain, in part, the popular use of this plant as a natural antinociceptive agent. This pharmacological action can be caused by flavonoids such as rutin and other compounds present in AESM.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul-
Descrição: dc.descriptionFederal University of Grande Dourados Faculty of Health Sciences, Mato Grosso do Sul State-
Descrição: dc.descriptionSchool of Health Sciences Unigran Capital University Center, Mato Grosso do Sul State-
Descrição: dc.descriptionPharmaceutical Sciences Food and Nutrition College Federal University of Mato Grosso Do Sul, Mato Grosso do Sul State-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University, São Paulo State-
Descrição: dc.descriptionEnvironment and Regional Development Postgraduate Program Anhanguera-Uniderp University, Mato Grosso do Sul State-
Descrição: dc.descriptionCenter of Studies in Natural Resources State University of Mato Grosso do Sul, Mato Grosso do Sul State-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University, São Paulo State-
Idioma: dc.languageen-
Relação: dc.relationJournal of Ethnopharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcipó-timbó-
Palavras-chave: dc.subjectCipó-uva-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectRutin-
Palavras-chave: dc.subjectStomach pain-
Título: dc.titleAntinociceptive and anti-inflammatory properties of aqueous extract obtained from Serjania marginata Casar leaves-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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