Testosterone replacement relieves ligature-induced periodontitis by mitigating inflammation, increasing pro-resolving markers and promoting angiogenesis in rats: A preclinical study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPontifical Catholic University of Minas Gerais-
Autor(es): dc.creatorPelegrin, Álvaro Formoso-
Autor(es): dc.creatorde Paiva Gonçalves, Vinícius-
Autor(es): dc.creatorCarvalho, Jhonatan de Souza-
Autor(es): dc.creatorSpolidorio, Denise Madalena Palomari-
Autor(es): dc.creatorSpolidorio, Luís Carlos-
Data de aceite: dc.date.accessioned2025-08-21T15:24:16Z-
Data de disponibilização: dc.date.available2025-08-21T15:24:16Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2022.105605-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249504-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249504-
Descrição: dc.descriptionObjectives: This study aimed to evaluate the inflammatory profile as well as the resolution of inflammation in a ligature-induced periodontal inflammation in rats with depletion and/or supraphysiological testosterone replacement. Design: Sixty male rats (Holtzman) were used in the present study. Study groups were created as following: (1) Sham (no testicle removal); (2) Orchiectomy (OCX), 3) OCX + Testosterone (OCX + T); (4) Sham + Ligature (SH + L); (5) OCX+L; and 6) OCX + T + L. The surgeries were performed on day 1, and testosterone was administered weekly since day 1. On day 15, a cotton ligature was placed around the lower first molars and maintained for 15 days. Morphological changes in periodontal tissues were determined by histopathological analysis. Immunohistochemistry (factor VIII) and immunoenzymatic assay were performed to evaluate angiogenesis process and (pro- and anti-) inflammatory markers, respectively. Results: Ligature promoted a marked inflammatory gingival infiltrate and bone loss (P < 0.05). Supraphysiological testosterone treatment increased the percentage of blood vessels, extracellular matrix and fibroblasts in the presence and absence of periodontal inflammation (P < 0.05). A high dose of testosterone increased factor VIII+ blood vessels and IL-10 expression in inflamed gingival tissue, while PGE2, LXA4 and MPO were reduced as a result of supraphysiological testosterone administration (P < 0.05). Conclusions: These results, in our experimental model, suggest that supraphysiological testosterone treatment stimulated gingival tissue repair during ligature-induced periodontitis, and it seems to be related to an anti-inflammatory and pro-resolutive mechanism resulting by the modulatory effect on PGE2 and IL-10 related to an enhanced angiogenesis.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University – UNESP, 1680 Humaitá St., – Center, SP-
Descrição: dc.descriptionDepartment of Dentistry Pontifical Catholic University of Minas Gerais, 500 Dom José Gaspar Avenue, – Coração Eucarístico, MG-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University – UNESP, 1680 Humaitá St., – Center, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University – UNESP, 1680 Humaitá St., – Center, SP-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University – UNESP, 1680 Humaitá St., – Center, SP-
Descrição: dc.descriptionCNPq: #147361/2018-4-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHormone replacement therapy-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectPeriodontal diseases-
Palavras-chave: dc.subjectTestosterone-
Título: dc.titleTestosterone replacement relieves ligature-induced periodontitis by mitigating inflammation, increasing pro-resolving markers and promoting angiogenesis in rats: A preclinical study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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