Potential in vitro action of an adenosine analog and synergism with penicillin against Corynebacterium pseudotuberculosis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of California – Davis-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorBernardino, Pedro Negri-
Autor(es): dc.creatorde Paula, Carolina Lechinski-
Autor(es): dc.creatorPereira, Ana Flávia Marques-
Autor(es): dc.creatorRibeiro, Márcio Garcia-
Autor(es): dc.creatorde Carvalho Azevedo, Vasco Ariston-
Autor(es): dc.creatorBorges, Alexandre Secorun-
Autor(es): dc.creatorFernandes-Júnior, Ary-
Autor(es): dc.creatorOliveira-Filho, José Paes-
Data de aceite: dc.date.accessioned2025-08-21T21:57:24Z-
Data de disponibilização: dc.date.available2025-08-21T21:57:24Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s42770-022-00885-0-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249483-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249483-
Descrição: dc.descriptionCaseous lymphadenitis is a well-known disease caused by Corynebacterium pseudotuberculosis affecting small ruminants with small significance to human health because of its minor zoonotic potential. In both cases, few treatment options are available and conventional antimicrobial therapy is commonly refractory due to development of pyogranulomatous reactions, bringing great interest in discovering novel therapeutics for more suitable approaches. Dideoxynucleotides presented antibacterial action against various bacteria but were never described for C. pseudotuberculosis. Hypothesizing the antimicrobial action of 2’,3’-dideoxiadenosine (ddATP) against C. pseudotuberculosis, we performed for the first time an investigation of its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) in the ATCC® 19,410 strain and a well-characterized clinical isolate of C. pseudotuberculosis. We also assessed potential synergism with penicillin. ddATP showed a growth delay effect for C. pseudotuberculosis at 2 µmol/mL and a MIC and MBC of 4 µmol/mL against the ATCC® 19,410 strain, but not for the clinical strain. An antimicrobial effect was observed when using concentrations lower than the MIC of ddATP associated with penicillin for both strains tested. Our data suggest the potential of nucleotide analogs, especially adenosine, and its combination with penicillin, as a possible novel treatment for C. pseudotuberculosis-induced infections, and contributes with knowledge regarding alternative drugs to treat C. pseudotuberculosis infections.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science São Paulo State University (UNESP)-
Descrição: dc.descriptionSchool of Veterinary Medicine Molecular Biosciences Department University of California – Davis-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionGenetics Ecology and Evolution Department Federal University of Minas Gerais-
Descrição: dc.descriptionSchool of Veterinary Medicine and Animal Science São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: 132282/2019-
Formato: dc.format559-563-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject2’,3’-Dideoxyadenosine-
Palavras-chave: dc.subjectBactericidal-
Palavras-chave: dc.subjectBacteriostatic-
Palavras-chave: dc.subjectCaseous lymphadenitis-
Palavras-chave: dc.subjectSmall ruminant-
Título: dc.titlePotential in vitro action of an adenosine analog and synergism with penicillin against Corynebacterium pseudotuberculosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.