Impact of Bifidobacterium animalis subsp. lactis HN019 probiotic in the prevention of periodontitis associated with immunosuppression

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Autor(es): dc.contributorUNOESTE – University of Western São Paulo-
Autor(es): dc.contributorUNOPAR – University Pitágoras UNOPAR-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMaia, Luciana Prado-
Autor(es): dc.creatorde Almeida Silva Levi, Yara Loyanne-
Autor(es): dc.creatorHenrique Félix Silva, Pedro-
Autor(es): dc.creatorCarla Wons, Luana-
Autor(es): dc.creatorPizzo Pitelli, Livia-
Autor(es): dc.creatorGoulart de Castro, Jéssica-
Autor(es): dc.creatorda Silva Dólens, Eder-
Autor(es): dc.creatorGregorio, Danielle-
Autor(es): dc.creatorGouveia Straioto, Fabiana-
Autor(es): dc.creatordos Santos Santinoni, Carolina-
Autor(es): dc.creatorCasarin, Renato-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorAparecida Chaves Furlaneto, Flávia-
Autor(es): dc.creatorReis Messora, Michel-
Data de aceite: dc.date.accessioned2025-08-21T22:48:57Z-
Data de disponibilização: dc.date.available2025-08-21T22:48:57Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/JPER.22-0146-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249475-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249475-
Descrição: dc.descriptionBackground: This study evaluated the effects of the probiotic Bifidobacterium animalis subsp. lactis HN019 (HN019) in the development of experimental periodontitis (EP) in rats submitted to chemotherapy (5-fluorouracil [5FU]). Methods: Eighty male rats were divided into the following groups: control (C); treated with 5FU (60 mg/kg at day 30 and 40 mg/kg at day 32); treated with probiotic (HN019) (daily, for 44 days, starting at day 0); treatment with 5FU and probiotic (5FU-HN019); only EP (EP) (ligature placed on lower first molars at day 30, maintained for 14 days); EP and treatment with 5FU (EP-5FU); EP and treatment with probiotic (EP-HN019); and EP and treatment with 5FU and probiotic (EP-5FU-HN019). Euthanasia occurred at day 44. Morphometric, histomorphometric, microtomographic, immunohistochemical, immunoenzymatic, and gene expressions analyses were performed. The data obtained were statistically analyzed (p < 0.05). Results: The EP-5FU-HN019 group showed less bone and connective tissue loss when compared with EP-5FU group, while EP-HN019 and EP-5FU-HN019 groups had greater bone volume than EP and EP-5FU groups, respectively (p < 0.05). A decrease in immunostaining for tartrate-resistant acid phosphatase and RANKL, an increase for osteoprotegerin and lower interleukin-1β levels were observed in EP-5FU-HN019 group, when compared with EP-5FU group (p < 0.0001). Probiotic therapy led to an increase in the proportions of B. lactis in the feces (p = 0.0018), but not in the biofilm, and reduced the expression of Fusobacterium nucleatum and Prevotella intermedia in the biofilm (p < 0.0001). Conclusion: B. lactis HN019 reduced the severity of EP in rats submitted to chemotherapy, modulating immunoinflammatory parameters in periodontal tissues and reducing periodontopathogens expression on biofilm in rats submitted to chemotherapy.-
Descrição: dc.descriptionGraduate Program in Dentistry UNOESTE – University of Western São Paulo, São Paulo-
Descrição: dc.descriptionGraduate Program in Dentistry UNOPAR – University Pitágoras UNOPAR, Paraná-
Descrição: dc.descriptionDepartment of Oral Surgery and Periodontology School of Dentistry of Ribeirão Preto University of São Paulo – USP, São Paulo-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontics School of Dentistry Campinas State University – UNICAMP, São Paulo-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University - UNESP, São Paulo-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University - UNESP, São Paulo-
Formato: dc.format389-404-
Idioma: dc.languageen-
Relação: dc.relationJournal of Periodontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantineoplastic agents-
Palavras-chave: dc.subjectbifidobacterium animalis-
Palavras-chave: dc.subjectperiodontitis-
Palavras-chave: dc.subjectprobiotics-
Título: dc.titleImpact of Bifidobacterium animalis subsp. lactis HN019 probiotic in the prevention of periodontitis associated with immunosuppression-
Tipo de arquivo: dc.typelivro digital-
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