Biocompatibility and bioactive potential of an experimental tricalcium silicate-based cement in comparison with Bio-C repair and MTA Repair HP materials

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorQueiroz, Marcela Borsatto-
Autor(es): dc.creatorInada, Rafaela N. H.-
Autor(es): dc.creatorJampani, José Leandro de Abreu-
Autor(es): dc.creatorGuerreiro-Tanomaru, Juliane Maria-
Autor(es): dc.creatorSasso-Cerri, Estela-
Autor(es): dc.creatorTanomaru-Filho, Mário-
Autor(es): dc.creatorCerri, Paulo Sérgio-
Data de aceite: dc.date.accessioned2025-08-21T17:20:25Z-
Data de disponibilização: dc.date.available2025-08-21T17:20:25Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/iej.13863-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249382-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249382-
Descrição: dc.descriptionAim: To evaluate the tissue reaction of a tricalcium silicate-based repair material associated with 30% calcium tungstate (TCS + CaWO4) in comparison to Bio-C Repair (Bio-C; Angelus) and to MTA Repair HP (MTA HP; Angelus). Methodology: Polyethylene tubes filled with one of the materials or left empty (control group, CG) were implanted into the subcutaneous tissues of rats for 7, 15, 30 and 60 days (n = 32/group). The capsule thickness, number of inflammatory cells, collagen content, interleukin-6 (IL-6), osteocalcin (OCN), von Kossa reaction and analysis under polarized light were evaluated. The data were subjected to generalized linear models for repeated measures, except the OCN. OCN data were submitted to Kruskal–Wallis and Dunn's post hoc test and Friedman followed by Nemenyi's test at significance level of 5%. Results: At all time points, significant differences in the number of inflammatory cells were not observed between TCS + CaWO4 and Bio-C, whereas, at 15, 30 and 60 days, no significant difference was detected between TCS + CaWO4 and MTA HP. At all periods, significant differences were not detected in the number of fibroblasts in TCS + CaWO4 versus MTA HP, and, at 60 days, no significant difference was demonstrated between these groups and CG. Significant differences in the immunoexpression of IL-6 were not detected amongst bioceramic materials at all periods. From 7 to 60 days, significant reduction in the number of inflammatory cells, number of IL-6-immunopositive cells and in the capsule thickness was accompanied by significant increase in the collagen in all groups. OCN-immunolabelled cells, von Kossa-positive structures and amorphous calcite deposits were observed around all materials, whereas, in the CG, these structures were not seen. Conclusions: These findings indicate that the experimental material (TCS + CaWO4) is biocompatible and has a bioactive potential, similar to the MTA HP and Bio-C Repair, and suggest its use as a root repair material.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Restorative Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Histology and Embryology Department of Morphology Genetics Orthodontics and Pediatric Dentistry Dental School São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Restorative Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Histology and Embryology Department of Morphology Genetics Orthodontics and Pediatric Dentistry Dental School São Paulo State University (UNESP)-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2019/17739-5-
Formato: dc.format259-277-
Idioma: dc.languageen-
Relação: dc.relationInternational Endodontic Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanimal model-
Palavras-chave: dc.subjectbioceramic materials-
Palavras-chave: dc.subjectinterleukin-6-
Palavras-chave: dc.subjectosteocalcin-
Palavras-chave: dc.subjectrepair materials-
Palavras-chave: dc.subjecttissue reaction-
Título: dc.titleBiocompatibility and bioactive potential of an experimental tricalcium silicate-based cement in comparison with Bio-C repair and MTA Repair HP materials-
Tipo de arquivo: dc.typelivro digital-
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