Prostate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUnimed Hospital-
Autor(es): dc.creatorCavalleri Sousa, Thainá-
Autor(es): dc.creatorde Oliveira, Camila Bonillo-
Autor(es): dc.creatorSilva Ricardo, Maria Luiza-
Autor(es): dc.creatorMusa de Aquino, Ariana-
Autor(es): dc.creatorScarano, Wellerson Rodrigo-
Autor(es): dc.creatorCruz Veras, Allice Santos-
Autor(es): dc.creatorAlmeida Tavares, Maria Eduarda-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo-
Autor(es): dc.creatorCastillho, Anthony César deSousa-
Autor(es): dc.creatorPacagnelli, Francis Lopes-
Autor(es): dc.creatorZalotti Brandt, Joyce-
Autor(es): dc.creatorde Oliveira Mendes, Leonardo-
Data de aceite: dc.date.accessioned2025-08-21T15:31:51Z-
Data de disponibilização: dc.date.available2025-08-21T15:31:51Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/09603123.2022.2140127-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249342-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249342-
Descrição: dc.descriptionBisphenol A (BPA) is an environmentally dispersed chemical associated with tumor development. Phytochemicals such as indole-3-carbinol (I3C) and genistein (GEN) have chemoprotective effects on tumor cells. Thus, this study aimed to evaluate the prostatic morphological aspects of rats exposed to BPA, GEN, and I3C during the perinatal period and submitted to hormonal stimulus in adulthood. Blood was collected to obtain hormone concentrations. Slides stained with hematoxylin & eosin, and picrosirius were subjected to fractal, stereological, morphometric, and collagen quantification analysis. I3C decreased the plasma dihydrotestosterone levels, and both phytochemicals increased the plasma estrogen levels. Unlike phytochemicals, BPA did not alter any of the parameters evaluated. GEN reduced the epithelial height, while I3C increased the fractal dimension and stromal collagen. Although BPA did not alter the prostate morphology, the phytochemicals provided beneficial effects for the prostate histological organization in adult animals subjected to hormonal stimulus.-
Descrição: dc.descriptionGraduate Program in Animal Science Western São Paulo University (UNOESTE)-
Descrição: dc.descriptionDepartment of Functional and Structural Biology IBB/UNESP-
Descrição: dc.descriptionExperimental Laboratory of Exercise Biology (LEBioEx) São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Nutrition Unimed Hospital-
Descrição: dc.descriptionMaster Program in Health Science Western São Paulo University (UNOESTE)-
Descrição: dc.descriptionDepartment of Functional and Structural Biology IBB/UNESP-
Descrição: dc.descriptionExperimental Laboratory of Exercise Biology (LEBioEx) São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Environmental Health Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEndocrine disruptors-
Palavras-chave: dc.subjectgenistein-
Palavras-chave: dc.subjectindole-3-carbinol-
Título: dc.titleProstate histological investigation in rats exposed to bisphenol a and phytochemicals during the perinatal period and subjected to hormonal stimulus in adulthood-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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