Development of New Natural Lipid-Based Nanoparticles Loaded with Aluminum-Phthalocyanine for Photodynamic Therapy against Melanoma

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Brasília-
Autor(es): dc.contributorCOOIL Institute-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.creatorMello, Victor Carlos-
Autor(es): dc.creatorAraújo, Victor Hugo Sousa-
Autor(es): dc.creatorde Paiva, Karen Letycia Rodrigues-
Autor(es): dc.creatorSimões, Marina Mesquita-
Autor(es): dc.creatorMarques, Dafne Caroline-
Autor(es): dc.creatorda Silva Costa, Nelice Roberta-
Autor(es): dc.creatorde Souza, Isadora Florêncio-
Autor(es): dc.creatorda Silva, Patricia Bento-
Autor(es): dc.creatorSantos, Igor-
Autor(es): dc.creatorAlmeida, Raquel-
Autor(es): dc.creatorMagalhães, Kelly Grace-
Autor(es): dc.creatorda Silva, Sebastião William-
Autor(es): dc.creatorSantos, Alexandre Silva-
Autor(es): dc.creatorVeiga-Souza, Fabiane-
Autor(es): dc.creatorSouza, Paulo Eduardo Narcizo-
Autor(es): dc.creatorRaddichi, Marina Arantes-
Autor(es): dc.creatorLongo, João Paulo Figueiró-
Autor(es): dc.creatorde Araújo, Jennifer Thayanne Cavalcante-
Autor(es): dc.creatorMuehlmann, Luis Alexandre-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorBáo, Sônia Nair-
Data de aceite: dc.date.accessioned2025-08-21T22:31:07Z-
Data de disponibilização: dc.date.available2025-08-21T22:31:07Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/nano12203547-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249318-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249318-
Descrição: dc.descriptionPhotodynamic therapy (PDT) mediated by photosensitizers loaded in nanostructures as solid lipid nanoparticles has been pinpointed as an effective and safe treatment against different skin cancers. Amazon butters have an interesting lipid composition when it comes to forming solid lipid nanoparticles (SLN). In the present report, a new third-generation photosensitizing system consisting of aluminum-phthalocyanine associated with Amazon butter-based solid lipid nanoparticles (SLN-AlPc) is described. The SLN was developed using murumuru butter, and a monodisperse population of nanodroplets with a hydrodynamic diameter of approximately 40 nm was obtained. The study of the permeation of these AlPc did not permeate the analyzed skin, but when incorporated into the system, SLN-AlPc allowed permeation of almost 100% with 8 h of contact. It must be emphasized that SLN-AlPc was efficient for carrying aluminum-phthalocyanine photosensitizers and exhibited no toxicity in the dark. Photoactivated SLN-AlPc exhibited a 50% cytotoxicity concentration (IC50) of 19.62 nM when applied to B16-F10 monolayers, and the type of death caused by the treatment was apoptosis. The exposed phospholipid phosphatidylserine was identified, and the treatment triggered a high expression of Caspase 3. A stable Amazon butter-based SLN-AlPc formulation was developed, which exhibits strong in vitro photodynamic activity on melanoma cells.-
Descrição: dc.descriptionFundação de Apoio à Pesquisa do Distrito Federal-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPostgraduate Program in Animal Biology Department of Genetics and Morphology Institute of Biological Sciences University of Brasília, DF-
Descrição: dc.descriptionLaboratory of Microscopy and Microanalysis Department of Cell Biology Institute of Biological Sciences University of Brasília, DF-
Descrição: dc.descriptionCOOIL Institute, DF-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University, SP-
Descrição: dc.descriptionLaboratory of Nanobiotechnology Department of Genetics and Morphology Institute of Biological Sciences University of Brasilia, DF-
Descrição: dc.descriptionLaboratory of Immunology and Inflammation Department of Cell Biology University of Brasilia, DF-
Descrição: dc.descriptionOptical Spectroscopy Laboratory Institute of Physics University of Brasilia, DF-
Descrição: dc.descriptionLaboratory of Protein Chemistry and Biochemistry Department of Cell Biology Institute of Biology University of Brasília, DF-
Descrição: dc.descriptionFaculty of Ceilandia University of Brasilia, DF-
Descrição: dc.descriptionLaboratory of Electron Paramagnetic Resonance Institute of Physics University of Brasília, DF-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University, SP-
Descrição: dc.descriptionFundação de Apoio à Pesquisa do Distrito Federal: 00193.00000920/2020-23-
Descrição: dc.descriptionFundação de Apoio à Pesquisa do Distrito Federal: 00193.00001053/2021-24-
Descrição: dc.descriptionCNPq: 302355/2016-2-
Descrição: dc.descriptionCNPq: 401957/2016-0-
Descrição: dc.descriptionCNPq: 40356/2021-
Idioma: dc.languageen-
Relação: dc.relationNanomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmazon butters-
Palavras-chave: dc.subjectcancer-
Palavras-chave: dc.subjectdrug delivery systems-
Palavras-chave: dc.subjectphotodynamic therapy-
Palavras-chave: dc.subjectthird-generation photosensitizers-
Título: dc.titleDevelopment of New Natural Lipid-Based Nanoparticles Loaded with Aluminum-Phthalocyanine for Photodynamic Therapy against Melanoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.