Biosynthesis of silver nanoparticles from Syzygium cumini leaves and their potential effects on odontogenic pathogens and biofilms

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorBernardo, Wagner Luis de Carvalho-
Autor(es): dc.creatorBoriollo, Marcelo Fabiano Gomes-
Autor(es): dc.creatorTonon, Caroline Coradi-
Autor(es): dc.creatorda Silva, Jeferson Júnior-
Autor(es): dc.creatorOliveira, Mateus Cardoso-
Autor(es): dc.creatorde Moraes, Fernando Cruz-
Autor(es): dc.creatorSpolidorio, Denise Madalena Palomari-
Data de aceite: dc.date.accessioned2025-08-21T22:20:34Z-
Data de disponibilização: dc.date.available2025-08-21T22:20:34Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-09-29-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fmicb.2022.995521-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249264-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249264-
Descrição: dc.descriptionThis study analyzed the antimicrobial and antibiofilm action and cytotoxicity of extract (HEScL) and silver nanoparticles (AgNPs-HEScL) from Syzygium cumini leaves. GC–MS, UV–Vis, EDX, FEG/SEM, DLS and zeta potential assays were used to characterize the extract or nanoparticles. Antimicrobial, antibiofilm and cytotoxicity analyses were carried out by in vitro methods: agar diffusion, microdilution and normal oral keratinocytes spontaneously immortalized (NOK-SI) cell culture. MICs of planktonic cells ranged from 31.2–250 (AgNPs-HEScL) to 1,296.8–10,375 μg/ml (HEScL) for Actinomyces naeslundii, Fusobacterium nucleatum, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, Streptococcus oralis, Veillonella dispar, and Candida albicans. AgNPs-HEScL showed antibiofilm effects (125–8,000 μg/ml) toward Candida albicans, Streptococcus mutans and Streptococcus oralis, and Staphylococcus aureus and Staphylococcus epidermidis. The NOK-SI exhibited no cytotoxicity when treated with 32.8 and 680.3 μg/ml of AgNPs-HEScL and HEScL, respectively, for 5 min. The data suggest potential antimicrobial and antibiofilm action of HEScL, and more specifically, AgNPs-HEScL, involving pathogens of medical and dental interest (dose-, time- and species-dependent). The cytotoxicity of HEScL and AgNPs-HEScL detected in NOK-SI was dose- and time-dependent. This study presents toxicological information about the lyophilized ethanolic extract of S. cumini leaves, including their metallic nanoparticles, and adds scientific values to incipient studies found in the literature.-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University-
Descrição: dc.descriptionDepartment of Oral Diagnosis Dental School of Piracicaba State University of Campinas-
Descrição: dc.descriptionSchool of Chemistry Federal University of São Carlos-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantibiofilm activity-
Palavras-chave: dc.subjectantimicrobial activity-
Palavras-chave: dc.subjectnormal oral keratinocytes spontaneously immortalized-
Palavras-chave: dc.subjectodontogenic pathogens-
Palavras-chave: dc.subjectsilver nanoparticles-
Palavras-chave: dc.subjectSyzygium cumini-
Título: dc.titleBiosynthesis of silver nanoparticles from Syzygium cumini leaves and their potential effects on odontogenic pathogens and biofilms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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