Vivaxin genes encode highly immunogenic, non-variant antigens on the Trypanosoma vivax cell-surface

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Liverpool-
Autor(es): dc.contributorLiverpool School of Tropical Medicine-
Autor(es): dc.contributorWellcome Genome Campus-
Autor(es): dc.contributorUniversity of York-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorThe Robert Gordon University-
Autor(es): dc.contributorWaterford Institute of Technology-
Autor(es): dc.creatorRomero-Ramirez, Alessandra-
Autor(es): dc.creatorCasas-Sánchez, Aitor-
Autor(es): dc.creatorAutheman, Delphine-
Autor(es): dc.creatorDuffy, Craig W.-
Autor(es): dc.creatorBrandt, Cordelia-
Autor(es): dc.creatorClare, Simon-
Autor(es): dc.creatorHarcourt, Katherine-
Autor(es): dc.creatorAndré, Marcos Rogério-
Autor(es): dc.creatorNeto, Kayo José Garcia de Almeida Castilho-
Autor(es): dc.creatorTeixeira, Marta M. G.-
Autor(es): dc.creatorMachado, Rosangela Zacharias-
Autor(es): dc.creatorCoombes, Janine-
Autor(es): dc.creatorFlynn, Robin J.-
Autor(es): dc.creatorWright, Gavin J.-
Autor(es): dc.creatorJackson, Andrew P.-
Data de aceite: dc.date.accessioned2025-08-21T17:08:51Z-
Data de disponibilização: dc.date.available2025-08-21T17:08:51Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1371/JOURNAL.PNTD.0010791-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249244-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249244-
Descrição: dc.descriptionTrypanosoma vivax is a unicellular hemoparasite, and a principal cause of animal African trypanosomiasis (AAT), a vector-borne and potentially fatal livestock disease across sub-Saharan Africa. Previously, we identified diverse T. vivax-specific genes that were predicted to encode cell surface proteins. Here, we examine the immune responses of naturally and experimentally infected hosts to these unique parasite antigens, to identify immunogens that could become vaccine candidates. Immunoprofiling of host serum shows that one particular family (Fam34) elicits a consistent IgG antibody response. This gene family, which we now call Vivaxin, encodes at least 124 transmembrane glycoproteins that display quite distinct expression profiles and patterns of genetic variation. We focused on one gene (viv-β8) that encodes one particularly immunogenic vivaxin protein and which is highly expressed during infections but displays minimal polymorphism across the parasite population. Vaccination of mice with VIVβ8 adjuvanted with Quil-A elicits a strong, balanced immune response and delays parasite proliferation in some animals but, ultimately, it does not prevent disease. Although VIVβ8 is localized across the cell body and flagellar membrane, live immunostaining indicates that VIVβ8 is largely inaccessible to antibody in vivo. However, our phylogenetic analysis shows that vivaxin includes other antigens shown recently to induce immunity against T. vivax. Thus, the introduction of vivaxin represents an important advance in our understanding of the T. vivax cell surface. Besides being a source of proven and promising vaccine antigens, the gene family is clearly an important component of the parasite glycocalyx, with potential to influence host-parasite interactions.-
Descrição: dc.descriptionConsejo Nacional de Ciencia, Tecnología e Innovación Tecnológica-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico-
Descrição: dc.descriptionInstitute of Infection Veterinary and Ecological Sciences University of Liverpool-
Descrição: dc.descriptionDepartment of Tropical Disease Biology Liverpool School of Tropical Medicine-
Descrição: dc.descriptionWellcome Trust Sanger Institute Wellcome Genome Campus-
Descrição: dc.descriptionDepartment of Biology Hull York Medical School York Biomedical Research Institute University of York-
Descrição: dc.descriptionDepartment of Pathology Reproduction and One Health Faculty of Agrarian and Veterinary Sciences São Paulo State University (UNESP), Sao Paulo-
Descrição: dc.descriptionDepartment of Parasitology Institute of Biomedical Sciences University of Sao Paulo, Sao Paulo-
Descrição: dc.descriptionSchool of Pharmacy and Life Sciences The Robert Gordon University-
Descrição: dc.descriptionWaterford Institute of Technology-
Descrição: dc.descriptionDepartment of Pathology Reproduction and One Health Faculty of Agrarian and Veterinary Sciences São Paulo State University (UNESP), Sao Paulo-
Idioma: dc.languageen-
Relação: dc.relationPLoS Neglected Tropical Diseases-
???dc.source???: dc.sourceScopus-
Título: dc.titleVivaxin genes encode highly immunogenic, non-variant antigens on the Trypanosoma vivax cell-surface-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.