Beta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Milan-
Autor(es): dc.contributorHarvard School of Dental Medicine-
Autor(es): dc.creatorHadad, Henrique-
Autor(es): dc.creatorKawamata de Jesus, Laís-
Autor(es): dc.creatorPiquera Santos, Ana Flávia-
Autor(es): dc.creatorRinaldi Matheus, Henrique-
Autor(es): dc.creatorde Souza Rodrigues, Letícia Gabriella-
Autor(es): dc.creatorPaolo Poli, Pier-
Autor(es): dc.creatorMarcantonio Junior, Elcio-
Autor(es): dc.creatorPozzi Semeghini Guastaldi, Fernando-
Autor(es): dc.creatorMaiorana, Carlo-
Autor(es): dc.creatorMilanezi de Almeida, Juliano-
Autor(es): dc.creatorOkamoto, Roberta-
Autor(es): dc.creatorÁvila Souza, Francisley-
Data de aceite: dc.date.accessioned2025-08-21T21:10:14Z-
Data de disponibilização: dc.date.available2025-08-21T21:10:14Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-022-20128-4-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249224-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249224-
Descrição: dc.descriptionSurgical trauma in those under a prolonged use of bisphosphonates, can lead to mediation-related osteonecrosis of the jaw (MRONJ). This study aimed to evaluate the preventive therapies for MRONJ. Following four cycles of zoledronic acid administration, Wistar rats had their molar extracted, and were organized into nine treatment groups: negative control group (NCG), treated with saline solution and blood-clot in the alveolus; positive control group (PCG), with blood-clot in the alveolus; BG, β-tricalcium phosphate-based biomaterial; DG, 10% doxycycline gel; aG, antimicrobial photodynamic therapy; and DBG, aBG, aDG, and aDBG, using combination therapy. After 28 days, the lowest bone volume (BV/TV) was reported in PCG (42.17% ± 2.65), and the highest in aDBG (69.85% ± 6.25) (p < 0.05). The higher values of daily mineral apposition rate were recorded in aDBG (2.64 ± 0.48) and DBG (2.30 ± 0.37) (p < 0.001). Moreover, aDBG presented with the highest neoformed bone area (82.44% ± 2.69) (p < 0.05). Non-vital bone was reported only in the PCG (37.94 ± 18.70%). Owing to the key role of the biomaterial, the combination approach (aDBG) was the most effective in preventing MRONJ following tooth extraction.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, São Paulo-
Descrição: dc.descriptionDepartment of Biomedical Surgical and Dental Sciences Implant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCCS Cá Granda Ospedale Maggiore Policlinico University of Milan-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionSkeletal Biology Research Center Department of Oral and Maxillofacial Surgery Massachusetts General Hospital (MGH) Harvard School of Dental Medicine-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP), 1193, José Bonifácio St, Vila Mendonça, São Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2019/22657-8-
Descrição: dc.descriptionFAPESP: 2019/27609-1-
Descrição: dc.descriptionCAPES: 88887.570145/2020-00-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleBeta tricalcium phosphate, either alone or in combination with antimicrobial photodynamic therapy or doxycycline, prevents medication-related osteonecrosis of the jaw-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.