Effect of maternal true combined endodontic-periodontal lesion on insulin and inflammatory pathway in adult offspring

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBelardi, Bianca Elvira-
Autor(es): dc.creatorMattera, Maria Sara de Lima Coutinho-
Autor(es): dc.creatorTsosura, Thaís Verônica Saori-
Autor(es): dc.creatordos Santos, Rodrigo Martins-
Autor(es): dc.creatorCantiga-Silva, Cristiane-
Autor(es): dc.creatorTavares Ângelo Cintra, Luciano-
Autor(es): dc.creatorChiba, Fernando Yamamoto-
Autor(es): dc.creatorBravo, Lara Teschi-
Autor(es): dc.creatorCarvalho, Nubia Ramos-
Autor(es): dc.creatorCarnevali, Ana Carolina Nascimento-
Autor(es): dc.creatorde Oliveira, Renan Akira Fujii-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorMatsushita, Doris Hissako-
Data de aceite: dc.date.accessioned2025-08-21T19:18:29Z-
Data de disponibilização: dc.date.available2025-08-21T19:18:29Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/JPER.22-0139-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249202-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249202-
Descrição: dc.descriptionBackground: Maternal periodontal disease (PED) and apical periodontitis (AP) are associated insulin resistance (IR), increased tumor necrosis factor-α (TNF-α) levels, and alterations in insulin signaling (IS) in the gastrocnemius muscle (GM) of adult offspring. TNF-α stimulates I kappa B kinase (IKK) and c-Jun N-terminal protein kinase (JNK), resulting in IS attenuation. However, studies that investigated the maternal true endodontic-periodontal lesion (EPL) in offspring are scarce, and in this case, the impact could be even higher. This study aimed to evaluate the effects of EPL on the IR, IS, and inflammatory pathways on the offspring GM. Methods: Female Wistar rats were distributed into control, AP, PED, and EPL groups. After 30 days of oral inflammation induction, rats from all groups were allowed to mate with healthy rats. The body weight of the offspring was assessed from birth to 75 days of age. After 75 days, the following measurements were performed: glycemia, insulinemia, IR, TNF-α content, and IKKα/β, JNK, pp185 (Tyr), and IRS-1 (Ser) phosphorylation status in the GM. Results: Maternal PED and EPL were associated with low birth weights. All maternal oral inflammations promoted IR and IS impairment in the GM and only maternal PED and EPL caused an increase in TNF-α content and IKKα/β phosphorylation status in the GM of offspring. The offspring of the rats with EPL group showed worsening of metabolic changes when compared with offspring of rats with AP or PED. Conclusion: Association of maternal AP and PED promoted a more pronounced worsening in the health of the adult offspring.-
Descrição: dc.descriptionPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas-SBFis Department of Basic Sciences School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences Botucatu Brazil and Department of Basic Sciences Division of Histology School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionPrograma de Pós-Graduação Multicêntrico em Ciências Fisiológicas-SBFis Department of Basic Sciences School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences Botucatu Brazil and Department of Basic Sciences Division of Histology School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP)-
Formato: dc.format487-497-
Idioma: dc.languageen-
Relação: dc.relationJournal of Periodontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectapical periodontitis-
Palavras-chave: dc.subjectinsulin resistance-
Palavras-chave: dc.subjectlow birth weight-
Palavras-chave: dc.subjectperiodontal diseases-
Palavras-chave: dc.subjecttumor necrosis factor-alpha-
Título: dc.titleEffect of maternal true combined endodontic-periodontal lesion on insulin and inflammatory pathway in adult offspring-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.