Non-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina Willd., a Brazilian semiarid native woody plant

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Autor(es): dc.contributorFederal University of Rio Grande do Norte (UFRN)-
Autor(es): dc.contributorCarlos Chagas Institute-
Autor(es): dc.contributorStanford University School of Medicine-
Autor(es): dc.contributorFederal University of Rio Grande do Sul-
Autor(es): dc.contributorRural Federal University of the Semiarid-
Autor(es): dc.contributorInstitute for Sustainable Development and Environment-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorStructural and Computational Biology Unit-
Autor(es): dc.contributorBarcelona Institute of Science and Technology-
Autor(es): dc.contributorLeiden University-
Autor(es): dc.contributorFederal University of Rio Grande do Norte-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.creatorChacon, Daisy Sotero-
Autor(es): dc.creatorSantos, Marlon Dias Mariano-
Autor(es): dc.creatorBonilauri, Bernardo-
Autor(es): dc.creatorVilasboa, Johnatan-
Autor(es): dc.creatorda Costa, Cibele Tesser-
Autor(es): dc.creatorda Silva, Ivanice Bezerra-
Autor(es): dc.creatorTorres, Taffarel de Melo-
Autor(es): dc.creatorde Araújo, Thiago Ferreira-
Autor(es): dc.creatorRoque, Alan de Araújo-
Autor(es): dc.creatorPilon, Alan Cesar-
Autor(es): dc.creatorSelegatto, Denise Medeiros-
Autor(es): dc.creatorFreire, Rafael Teixeira-
Autor(es): dc.creatorReginaldo, Fernanda Priscila Santos-
Autor(es): dc.creatorVoigt, Eduardo Luiz-
Autor(es): dc.creatorZuanazzi, José Angelo Silveira-
Autor(es): dc.creatorScortecci, Kátia Castanho-
Autor(es): dc.creatorCavalheiro, Alberto José-
Autor(es): dc.creatorLopes, Norberto Peporine-
Autor(es): dc.creatorFerreira, Leandro De Santis-
Autor(es): dc.creatorSantos, Leandro Vieira dos-
Autor(es): dc.creatorFontes, Wagner-
Autor(es): dc.creatorSousa, Marcelo Valle de-
Autor(es): dc.creatorCarvalho, Paulo Costa-
Autor(es): dc.creatorFett-Neto, Arthur Germano-
Autor(es): dc.creatorGiordani, Raquel Brandt-
Data de aceite: dc.date.accessioned2025-08-21T21:02:45Z-
Data de disponibilização: dc.date.available2025-08-21T21:02:45Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-09-08-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fpls.2022.947558-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249173-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249173-
Descrição: dc.descriptionErythrina velutina is a Brazilian native tree of the Caatinga (a unique semiarid biome). It is widely used in traditional medicine showing anti-inflammatory and central nervous system modulating activities. The species is a rich source of specialized metabolites, mostly alkaloids and flavonoids. To date, genomic information, biosynthesis, and regulation of flavonoids remain unknown in this woody plant. As part of a larger ongoing research goal to better understand specialized metabolism in plants inhabiting the harsh conditions of the Caatinga, the present study focused on this important class of bioactive phenolics. Leaves and seeds of plants growing in their natural habitat had their metabolic and proteomic profiles analyzed and integrated with transcriptome data. As a result, 96 metabolites (including 43 flavonoids) were annotated. Transcripts of the flavonoid pathway totaled 27, of which EvCHI, EvCHR, EvCHS, EvCYP75A and EvCYP75B1 were identified as putative main targets for modulating the accumulation of these metabolites. The highest correspondence of mRNA vs. protein was observed in the differentially expressed transcripts. In addition, 394 candidate transcripts encoding for transcription factors distributed among the bHLH, ERF, and MYB families were annotated. Based on interaction network analyses, several putative genes of the flavonoid pathway and transcription factors were related, particularly TFs of the MYB family. Expression patterns of transcripts involved in flavonoid biosynthesis and those involved in responses to biotic and abiotic stresses were discussed in detail. Overall, these findings provide a base for the understanding of molecular and metabolic responses in this medicinally important species. Moreover, the identification of key regulatory targets for future studies aiming at bioactive metabolite production will be facilitated.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstituto Nacional de Ciência e Tecnologia em Biodiversidade e Produtos Naturais-
Descrição: dc.descriptionInstituto Serrapilheira-
Descrição: dc.descriptionDepartment of Pharmacy Federal University of Rio Grande do Norte (UFRN), RN-
Descrição: dc.descriptionComputational and Structural Proteomics Laboratory Carlos Chagas Institute, PR-
Descrição: dc.descriptionStanford Cardiovascular Institute Stanford University School of Medicine-
Descrição: dc.descriptionPlant Physiology Laboratory Center for Biotechnology and Department of Botany Federal University of Rio Grande do Sul, RS-
Descrição: dc.descriptionBioinformatics Biostatistics and Computer Biology Nucleus Rural Federal University of the Semiarid, RN-
Descrição: dc.descriptionInstitute for Sustainable Development and Environment, Dunas Park Herbarium, RN-
Descrição: dc.descriptionNPPNS Department of Biomolecular Sciences Faculty of Pharmaceutical Sciences of Ribeirão Preto University of São Paulo (FCFRP-USP), SP-
Descrição: dc.descriptionZimmermann Group European Molecular Biology Laboratory (EMBL) Structural and Computational Biology Unit-
Descrição: dc.descriptionSignal and Information Processing for Sensing Systems Institute for Bioengineering of Catalonia (IBEC) Barcelona Institute of Science and Technology-
Descrição: dc.descriptionInstitute of Biology Leiden University-
Descrição: dc.descriptionDepartment of Cell Biology and Genetics Center for Biosciences Federal University of Rio Grande do Norte, RN-
Descrição: dc.descriptionLaboratory of Pharmacognosy Federal University of Rio Grande do Sul, RS-
Descrição: dc.descriptionChemistry Institute São Paulo State University (UNESP), SP-
Descrição: dc.descriptionGenetics and Molecular Biology Graduate Program Institute of Biology University of Campinas-
Descrição: dc.descriptionLaboratory of Protein Chemistry and Biochemistry Department of Cell Biology University of Brasilia, DF-
Descrição: dc.descriptionChemistry Institute São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Plant Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCaatinga-
Palavras-chave: dc.subjectErythrina velutina-
Palavras-chave: dc.subjectflavonoids-
Palavras-chave: dc.subjectmolecular network-
Palavras-chave: dc.subjecttranscriptome-
Título: dc.titleNon-target molecular network and putative genes of flavonoid biosynthesis in Erythrina velutina Willd., a Brazilian semiarid native woody plant-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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