The biocompatibility and antifungal effect of Rosmarinus officinalis against Candida albicans in Galleria mellonella model

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMeccatti, Vanessa Marques-
Autor(es): dc.creatorFigueiredo-Godoi, Lívia Mara Alves-
Autor(es): dc.creatorPereira, Thaís Cristine-
Autor(es): dc.creatorde Lima, Patrícia Michelle Nagai-
Autor(es): dc.creatorAbu Hasna, Amjad-
Autor(es): dc.creatorSenna, Lavinia Barbosa-
Autor(es): dc.creatorMarcucci, Maria Cristina-
Autor(es): dc.creatorJunqueira, Juliana Campos-
Autor(es): dc.creatorde Oliveira, Luciane Dias-
Data de aceite: dc.date.accessioned2025-08-21T22:33:23Z-
Data de disponibilização: dc.date.available2025-08-21T22:33:23Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-022-19425-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249159-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249159-
Descrição: dc.descriptionThis study was performed to evaluate the biocompatibility and antifungal effect of Rosmarinus officinalis against Candida albicans in Galleria mellonella model. Five different concentrations of R. officinalis glycolic extract (50; 25; 12.5 e 6.25 mg/mL) were used to evaluate its biocompatibility in G. mellonella model, in which the nystatin suspension (100; 50; 25; 12.5 e 6.25%) was used as a control group. The antifungal action of R. officinalis glycolic extract was evaluated on C. albicans for 72, 48 and 12 h at two different phases: (1) using the extract as therapeutic agent; and (2) using the extract as prophylactic agent. PBS was used as a negative control group. G. mellonella survival curves were plotted using the Kaplan–Meier method and statistical analysis was performed using the log-rank test (Mantel–Cox) and the significance level was set at (α ≤ 0.05). There was no significant difference among the groups in which all were biocompatible except of a significant death rate of 26.6% with nystatin 100%. In phase 1, it was found that after 7 days, there was no statistically significant difference among the prophylactic treatment groups. In phase 2, the groups of R. officinalis 6.25 mg/mL for 72 h and R. officinalis of 12.5 mg/mL for 24 h promoted the survival rate of the larvae in comparison with the control group with a significant difference (p = 0.017) and (p = 0.032) respectively. Therefore, R. officinalis extract is biocompatible in different concentrations and can be used as a prophylactic agent against fungal infection.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (ICT-UNESP), SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP), Av. Eng. Francisco José Longo Avenue 777, SP-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (ICT-UNESP), SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP), Av. Eng. Francisco José Longo Avenue 777, SP-
Descrição: dc.descriptionFAPESP: 15/25338-0-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleThe biocompatibility and antifungal effect of Rosmarinus officinalis against Candida albicans in Galleria mellonella model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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