The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats

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Autor(es): dc.contributorUniversity of Western São Paulo (UNOESTE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Northern Paraná (UNOPAR)-
Autor(es): dc.contributorUniversity of Nebraska-Lincoln-
Autor(es): dc.creatorEngel, Letícia Estevam-
Autor(es): dc.creatorde Souza, Francilene Lima Agostinho-
Autor(es): dc.creatorGiometti, Ines Cristina-
Autor(es): dc.creatorOkoshi, Katashi-
Autor(es): dc.creatorMariano, Thaoan Bruno-
Autor(es): dc.creatorFerreira, Natalia Zamberlan-
Autor(es): dc.creatorPinheiro, Dyovana Gomes-
Autor(es): dc.creatorFloriano, Rafael Stuani-
Autor(es): dc.creatorAguiar, Andreo Fernando-
Autor(es): dc.creatorCicogna, Antônio Carlos-
Autor(es): dc.creatorVechetti, Ivan José-
Autor(es): dc.creatorPacagnelli, Francis Lopes-
Data de aceite: dc.date.accessioned2025-08-21T17:46:31Z-
Data de disponibilização: dc.date.available2025-08-21T17:46:31Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2022.120959-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249155-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249155-
Descrição: dc.descriptionAim: To evaluate the influence of high-intensity interval training (HIIT) on cardiac structural and functional characteristics and myocardial mitogen-activated protein kinase (MAPK) signaling in hypertensive rats. Methods: Male rats (12 months old) were divided into three groups: Wistar Kyoto rats (WKY, n = 8); sedentary spontaneously hypertensive rats (SED-SHR, n = 10), and trained spontaneously hypertensive rats (HIIT-SHR, n = 10). Systolic blood pressure (SBP), functional capacity, echocardiography, isolated papillary muscle, and gene expression of MAPK gene-encoding proteins associated with Elk1, cJun, ATF2, MEF2 were analyzed. Key findings: HIIT decreased SBP and increased functional capacity, left ventricular diastolic diameter, posterior wall thickness-left ventricle, relative wall thickness-left ventricle, and resting tension of the papillary muscle. In hypertensive rats, we observed a decrease in the gene-encoding ATF2 protein; this decrease was reversed by HIIT. Significance: The influence of HIIT in the SHR model in the compensated hypertension phase generated an increase in cardiac hypertrophy, attenuated myocardial diastolic dysfunction, lowered blood pressure, improved functional capacity, and reversed the alteration in gene-encoding ATF2 protein.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionUniversity of Western São Paulo (UNOESTE), SP-
Descrição: dc.descriptionSão Paulo State University (UNESP), SP-
Descrição: dc.descriptionUniversity of Northern Paraná (UNOPAR), PR-
Descrição: dc.descriptionUniversity of Nebraska-Lincoln Department of Nutrition and Health Sciences-
Descrição: dc.descriptionSão Paulo State University (UNESP), SP-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 139942/2017-3-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectMAP kinase signaling system-
Palavras-chave: dc.subjectPapillary muscles-
Palavras-chave: dc.subjectPhysical exercise-
Título: dc.titleThe high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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