Swimming training attenuates the decrease of calcium responsiveness in female infarcted rats

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorPortes, Leslie Andrews-
Autor(es): dc.creatordos Santos, Alexandra Alberta-
Autor(es): dc.creatorPadovani, Carlos Roberto-
Autor(es): dc.creatorOliveira, Natália Cristina de-
Autor(es): dc.creatorSerra, Andrey Jorge-
Autor(es): dc.creatorTucci, Paulo J. F.-
Data de aceite: dc.date.accessioned2025-08-21T17:55:19Z-
Data de disponibilização: dc.date.available2025-08-21T17:55:19Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2022-08-22-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2022.923603-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249143-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249143-
Descrição: dc.descriptionAim: To evaluate the influence of swimming training on calcium responsiveness of the myocardium of rats with different infarction sizes (MI). Method: female Wistar rats, sedentary sham (SS = 14), sedentary moderate MI (SMI = 8) and sedentary large MI (SLI = 10) were compared to trained sham (TS = 16), trained moderate MI (TMI = 9) and trained large MI (TLI = 10). After 4 weeks of MI, the animals swam for 60 min/day, 5 days/week, for additional 8 weeks. Papillary muscles of the left ventricle were subjected to different concentrations of extracellular calcium. Inotropism was evaluated through the developed tension (DT), the maximum positive value of the first temporal derivation (+Td/td) and the time to peak tension (TPT). Lusitropism was evaluated by the maximum negative value of the first temporal derivation (−Td/td) and time to 50% relaxation (50%TR). Statistical significance was determined using multivariate analysis of variance and a Hotelling T2 test for the absolute power values of all four extracellular calcium concentrations (p < 0.05). Results: MI depressed inotropism (from 17% to 51%) and lusitropism (from 22% to 54%) of the sedentary rats, but exercise attenuated the losses, especially regarding + dT/dt, TPT, −dT/dt and 50%TR. Exercise attenuated the decrease in myocardial responsiveness, proportionally to the size of the MI. Conclusion: Myocardial calcium responsiveness is favorably affected in animals with moderate and large MI after swimming exercise.-
Descrição: dc.descriptionProfessor at UNASP Researcher at LAFEX Laboratory of Exercise Physiology Adventist University of Sao Paulo-
Descrição: dc.descriptionLaboratory of Cardiac Physiology and Cardiovascular Physiopathology Federal University of Sao Paulo-
Descrição: dc.descriptionDepartment of Biostatistics Bioscience Institute UNESP-State University of Sao Paulo-
Descrição: dc.descriptionMaster Degree Program in Health Promotion UNASP-Adventist University of São Paulo-
Descrição: dc.descriptionDepartment of Biostatistics Bioscience Institute UNESP-State University of Sao Paulo-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcalcium responsivity-
Palavras-chave: dc.subjectexercise training-
Palavras-chave: dc.subjectinoprotpism-
Palavras-chave: dc.subjectlusitropism-
Palavras-chave: dc.subjectmyocardial infarction-
Palavras-chave: dc.subjectrats-
Palavras-chave: dc.subjectswimming exercise-
Título: dc.titleSwimming training attenuates the decrease of calcium responsiveness in female infarcted rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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