Physical Training vs. Perindopril Treatment on Arterial Stiffening of Spontaneously Hypertensive Rats: A Proteomic Analysis and Possible Mechanisms

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorMiotto, Danyelle Siqueira-
Autor(es): dc.creatorDuchatsch, Francine-
Autor(es): dc.creatorDionizio, Aline-
Autor(es): dc.creatorBuzalaf, Marília Afonso Rabelo-
Autor(es): dc.creatorAmaral, Sandra Lia-
Data de aceite: dc.date.accessioned2025-08-21T19:50:08Z-
Data de disponibilização: dc.date.available2025-08-21T19:50:08Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/biomedicines11051381-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249095-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249095-
Descrição: dc.description(1) Background: Arterial stiffness is an important predictor of cardiovascular events. Perindopril and physical exercise are important in controlling hypertension and arterial stiffness, but the mechanisms are unclear. (2) Methods: Thirty-two spontaneously hypertensive rats (SHR) were evaluated for eight weeks: SHRC (sedentary); SHRP (sedentary treated with perindopril—3 mg/kg) and SHRT (trained). Pulse wave velocity (PWV) analysis was performed, and the aorta was collected for proteomic analysis. (3) Results: Both treatments determined a similar reduction in PWV (−33% for SHRP and −23% for SHRT) vs. SHRC, as well as in BP. Among the altered proteins, the proteomic analysis identified an upregulation of the EH domain-containing 2 (EHD2) protein in the SHRP group, required for nitric oxide-dependent vessel relaxation. The SHRT group showed downregulation of collagen-1 (COL1). Accordingly, SHRP showed an increase (+69%) in the e-NOS protein level and SHRT showed a lower COL1 protein level (−46%) compared with SHRC. (4) Conclusions: Both perindopril and aerobic training reduced arterial stiffness in SHR; however, the results suggest that the mechanisms can be distinct. While treatment with perindopril increased EHD2, a protein involved in vessel relaxation, aerobic training decreased COL1 protein level, an important protein of the extracellular matrix (ECM) that normally enhances vessel rigidity.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences (PIPGCF) Federal University of Sao Carlos and São Paulo State University UFSCar/UNESP-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo—USP-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences São Paulo State University—UNESP-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences (PIPGCF) Federal University of Sao Carlos and São Paulo State University UFSCar/UNESP-
Descrição: dc.descriptionDepartment of Physical Education School of Sciences São Paulo State University—UNESP-
Descrição: dc.descriptionCAPES: #88887.634301/2021-00-
Descrição: dc.descriptionCAPES: #88887.634304/2021-00-
Idioma: dc.languageen-
Relação: dc.relationBiomedicines-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcollagen and aerobic training-
Palavras-chave: dc.subjectperindopril-
Palavras-chave: dc.subjectpulse wave velocity-
Palavras-chave: dc.subjectSHR-
Título: dc.titlePhysical Training vs. Perindopril Treatment on Arterial Stiffening of Spontaneously Hypertensive Rats: A Proteomic Analysis and Possible Mechanisms-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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