Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSantos, Bruna M.-
Autor(es): dc.creatorSantos, Wanderson S.-
Autor(es): dc.creatorSolon, Isabelly G.-
Autor(es): dc.creatorGarcia, Felipe S.-
Autor(es): dc.creatorEmilio-Silva, Maycon T.-
Autor(es): dc.creatorJesus, Aline A.-
Autor(es): dc.creatorHiruma-Lima, Clélia A.-
Autor(es): dc.creatorNascimento, Glauce C.-
Autor(es): dc.creatorCárnio, Evelin C.-
Autor(es): dc.creatorBranco, Luiz G.S.-
Data de aceite: dc.date.accessioned2025-08-21T16:53:04Z-
Data de disponibilização: dc.date.available2025-08-21T16:53:04Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2023.105734-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249085-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249085-
Descrição: dc.descriptionOrofacial pain has significant psychological and physiological effects. Citral (3,7-dimethyl-2,6-octadienal) is the main component of Cymbopogon citratus (DC) Stapf, an herb with analgesic properties. Although citral has been considered a potent analgesic, its putative effects on orofacial pain are still unknown. Objective: The objective of this study is to test the hypothesis that citral modulates orofacial pain using two experimental models: formalin-induced hyperalgesia in the vibrissae area and during persistent temporomandibular hypernociception using Complete Freund's Adjuvant - CFA test. Methods: For the formalin test, citral (100 and 300 mg/kg, oral gavage) or its vehicle (Tween 80, 1 %) were given 1 h before the formalin injection subcutaneously (sc) into the vibrissae area. For the CFA model, we analyzed the prophylactic (100 mg/kg of citral by oral gavage, 1 h before CFA injection) and the chronic therapeutic (citral treatment 1-hour post-CFA injection and daily post-CFA injection) effect of citral or its vehicle in animals treated with CFA for 8 days. Results: Citral caused a decrease in formalin-induced local inflammation and the time spent performing nociceptive behavior in a dose-dependent fashion. Similarly, prophylactic and therapeutic citral treatment decreased the CFA-induced persistent mechanical hypernociception in the temporomandibular area. Conclusion: Our data strengthen the notion that citral plays a powerful antinociceptive role by decreasing orofacial hypernociception in formalin and CFA models.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Basic and Oral Biology Dental School of Ribeirão Preto University of São Paulo, Avenida Do Café s/n, São Paulo, SP-
Descrição: dc.descriptionDepartment of General and Specialized Nursing Ribeirão Preto College of Nursing - University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology (Physiology) Biosciences Institute UNESP-São Paulo State University, SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology (Physiology) Biosciences Institute UNESP-São Paulo State University, SP-
Descrição: dc.descriptionFAPESP: #16/09364-3-
Descrição: dc.descriptionFAPESP: #16/17681-9-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectComplete Freund's Adjuvant-
Palavras-chave: dc.subjectFormalin-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectOrofacial pain-
Palavras-chave: dc.subjectTemporomandibular disorders-
Palavras-chave: dc.subjectTrigeminal system-
Título: dc.titleOrofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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