New Insights into the Impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Michigan School of Dentistry-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Vienna-
Autor(es): dc.contributorBrazilian Center for Research in Energy and Materials (CNPEM)-
Autor(es): dc.contributorA.C.Camargo Cancer Center (CIPE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCancer Institute of the State of São Paulo (ICESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorA.C.Camargo Cancer Center-
Autor(es): dc.contributorUniversity of Michigan-
Autor(es): dc.creatorMiranda-Galvis, Marisol-
Autor(es): dc.creatorCarneiro Soares, Carolina-
Autor(es): dc.creatorMoretto Carnielli, Carolina-
Autor(es): dc.creatorRamalho Buttura, Jaqueline-
Autor(es): dc.creatorSales de Sá, Raisa-
Autor(es): dc.creatorKaminagakura, Estela-
Autor(es): dc.creatorMarchi, Fabio Albuquerque-
Autor(es): dc.creatorPaes Leme, Adriana Franco-
Autor(es): dc.creatorLópes Pinto, Clóvis A.-
Autor(es): dc.creatorSantos-Silva, Alan Roger-
Autor(es): dc.creatorMoraes Castilho, Rogerio-
Autor(es): dc.creatorKowalski, Luiz Paulo-
Autor(es): dc.creatorSquarize, Cristiane Helena-
Data de aceite: dc.date.accessioned2025-08-21T21:57:41Z-
Data de disponibilização: dc.date.available2025-08-21T21:57:41Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cells12091323-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249078-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249078-
Descrição: dc.descriptionHuman papillomavirus (HPV) infection has recently been linked to a subset of cancers affecting the oral cavity. However, the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) onset and progression are poorly understood. Methods: We performed MS-based proteomics profiling based on HPV status in OSCC in young patients, following biological characterization and cell assays to explore the proteome functional landscape. Results: Thirty-nine proteins are differentially abundant between HPV (+) and HPV (−) OSCC. Among them, COPS3, DYHC1, and S100A8 are unfavorable for tumor recurrence and survival, in contrast to A2M and Serpine1, low levels of which show an association with better DFS. Remarkably, S100A8 is considered an independent prognostic factor for lower survival rates, and at high levels, it alters tumor-associated immune profiling, showing a lower proportion of M1 macrophages and dendritic cells. HPV (+) OSCC also displayed the pathogen-associated patterns receptor that, when activated, triggered the S100A8 and NFκB inflammatory responses. Conclusion: HPV (+) OSCC has a peculiar microenvironment pattern distinctive from HPV (−), involving the expression of pathogen-associated pattern receptors, S100A8 overexpression, and NFκB activation and responses, which has important consequences in prognosis and may guide therapeutic decisions.-
Descrição: dc.descriptionFaculty of Medicine, University of British Columbia-
Descrição: dc.descriptionLaboratory of Epithelial Biology Department of Periodontics and Oral Medicine University of Michigan School of Dentistry-
Descrição: dc.descriptionOral Diagnosis Department Piracicaba Dental School University of Campinas (UNICAMP), SP-
Descrição: dc.descriptionDepartment of Microbiology Immune Biology and Genetics Center for Molecular Biology University of Vienna-
Descrição: dc.descriptionBrazilian Biosciences National Laboratory (LNBio) Brazilian Center for Research in Energy and Materials (CNPEM), SP-
Descrição: dc.descriptionLaboratory of Bioinformatics and Computational Biology A.C.Camargo Cancer Center (CIPE), SP-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Science and Technology Institute University of São Paulo State (UNESP), SP-
Descrição: dc.descriptionCenter for Translational Research in Oncology Cancer Institute of the State of São Paulo (ICESP), SP-
Descrição: dc.descriptionComprehensive Center for Precision Oncology University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Anatomic Pathology A.C.Camargo Cancer Center, SP-
Descrição: dc.descriptionRogel Cancer Center University of Michigan-
Descrição: dc.descriptionHead and Neck Surgery Department Medical School University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Head and Neck Surgery and Otorhinolaryngology A.C.Camargo Cancer Center, SP-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Science and Technology Institute University of São Paulo State (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationCells-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHPV-
Palavras-chave: dc.subjectoral cancer-
Palavras-chave: dc.subjectprognosis-
Palavras-chave: dc.subjectproteomics-
Palavras-chave: dc.subjectS100A8-
Título: dc.titleNew Insights into the Impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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