Virulence Profiles of Wild-Type, P.1 and Delta SARS-CoV-2 Variants in K18-hACE2 Transgenic Mice

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorOswaldo Cruz Foundation-
Autor(es): dc.contributorHospital Israelita Albert Einstein-
Autor(es): dc.contributorMacquarie University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.contributorCruzeiro do Sul University-
Autor(es): dc.creatorda Silva Santos, Yasmin-
Autor(es): dc.creatorGamon, Thais Helena Martins-
Autor(es): dc.creatorde Azevedo, Marcela Santiago Pacheco-
Autor(es): dc.creatorTelezynski, Bruna Larotonda-
Autor(es): dc.creatorde Souza, Edmarcia Elisa-
Autor(es): dc.creatorde Oliveira, Danielle Bruna Leal-
Autor(es): dc.creatorDombrowski, Jamille Gregório-
Autor(es): dc.creatorRosa-Fernandes, Livia-
Autor(es): dc.creatorPalmisano, Giuseppe-
Autor(es): dc.creatorde Moura Carvalho, Leonardo José-
Autor(es): dc.creatorLuvizotto, Maria Cecília Rui-
Autor(es): dc.creatorWrenger, Carsten-
Autor(es): dc.creatorCovas, Dimas Tadeu-
Autor(es): dc.creatorCuri, Rui-
Autor(es): dc.creatorMarinho, Claudio Romero Farias-
Autor(es): dc.creatorDurigon, Edison Luiz-
Autor(es): dc.creatorEpiphanio, Sabrina-
Data de aceite: dc.date.accessioned2025-08-21T15:34:38Z-
Data de disponibilização: dc.date.available2025-08-21T15:34:38Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/v15040999-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249074-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249074-
Descrição: dc.descriptionSince December 2019, the world has been experiencing the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and we now face the emergence of several variants. We aimed to assess the differences between the wild-type (Wt) (Wuhan) strain and the P.1 (Gamma) and Delta variants using infected K18-hACE2 mice. The clinical manifestations, behavior, virus load, pulmonary capacity, and histopathological alterations were analyzed. The P.1-infected mice showed weight loss and more severe clinical manifestations of COVID-19 than the Wt and Delta-infected mice. The respiratory capacity was reduced in the P.1-infected mice compared to the other groups. Pulmonary histological findings demonstrated that a more aggressive disease was generated by the P.1 and Delta variants compared to the Wt strain of the virus. The quantification of the SARS-CoV-2 viral copies varied greatly among the infected mice although it was higher in P.1-infected mice on the day of death. Our data revealed that K18-hACE2 mice infected with the P.1 variant develop a more severe infectious disease than those infected with the other variants, despite the significant heterogeneity among the mice.-
Descrição: dc.descriptionLaboratory of Cellular and Molecular Immunopathology of Malaria Department of Clinical and Toxicological Analysis Faculty of Pharmaceutical Sciences University of São Paulo-
Descrição: dc.descriptionLaboratory of Malaria Research Oswaldo Cruz Institute Oswaldo Cruz Foundation-
Descrição: dc.descriptionLaboratory of Clinical and Molecular Virology Department of Microbiology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionLaboratory of Experimental Immunoparasitology Department of Parasitology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionUnit for Drug Discovery Department of Parasitology Institute of Biomedical Sciences University of São Paulo-
Descrição: dc.descriptionHospital Israelita Albert Einstein-
Descrição: dc.descriptionGlycoProteomics Laboratory Department of Parasitology ICB University of São Paulo-
Descrição: dc.descriptionSchool of Natural Sciences Macquarie University-
Descrição: dc.descriptionSchool of Veterinary Medicine of Araçatuba São Paulo State University-
Descrição: dc.descriptionButantan Institute-
Descrição: dc.descriptionRibeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionInterdisciplinary Program of Health Sciences Cruzeiro do Sul University-
Descrição: dc.descriptionImmunobiological Production Section Bioindustrial Center Butantan Institute-
Descrição: dc.descriptionScientific Plataform Pasteur/USP University of São Paulo-
Descrição: dc.descriptionSchool of Veterinary Medicine of Araçatuba São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationViruses-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectDelta variant-
Palavras-chave: dc.subjectGamma variant-
Palavras-chave: dc.subjectK18-hACE2-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectvariants of concern-
Título: dc.titleVirulence Profiles of Wild-Type, P.1 and Delta SARS-CoV-2 Variants in K18-hACE2 Transgenic Mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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