Plasma Fibrinogen as a Predictor of Perioperative-Blood-Component Transfusion in Major-Nontraumatic-Orthopedic-Surgery Patients: A Cohort Study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSão Vicente de Paulo Hospital-
Autor(es): dc.creatorPagnussatt Neto, Eugenio-
Autor(es): dc.creatorLopes da Costa, Paula Daniele-
Autor(es): dc.creatorGurgel, Sanderland J. Tavares-
Autor(es): dc.creatorSchmidt Azevedo, Paula-
Autor(es): dc.creatorModolo, Norma S. Pinheiro-
Autor(es): dc.creatordo Nascimento Junior, Paulo-
Data de aceite: dc.date.accessioned2025-08-21T19:21:47Z-
Data de disponibilização: dc.date.available2025-08-21T19:21:47Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/diagnostics13050976-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249048-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249048-
Descrição: dc.descriptionThere is a trend towards increased perioperative bleeding in patients with plasma fibrinogen levels < 200 mg/dL−1. This study aimed to assess whether there is an association between preoperative fibrinogen levels and perioperative blood-product transfusion up to 48 h after major orthopedic surgery. This cohort study included 195 patients who underwent primary or revision hip arthroplasty for nontraumatic etiologies. Plasma fibrinogen, blood count, coagulation tests, and platelet count were measured preoperatively. A plasma fibrinogen level of 200 mg/dL−1 was the cutoff value used to predict blood transfusion. The mean (SD) plasma fibrinogen level was 325 (83) mg/dL−1. Only thirteen patients had levels < 200 mg/dL−1, and only one of them received a blood transfusion, with an absolute risk of 7.69% (1/13; 95%CI: 1.37–33.31%). Preoperative plasma fibrinogen levels were not associated with the need for blood transfusion (p = 0.745). The sensitivity and the positive predictive value of plasma fibrinogen < 200 mg/dL−1 as a predictor of blood transfusion were 4.17% (95%CI: 0.11–21.12%) and 7.69% (95%CI: 1.12–37.99%), respectively. Test accuracy was 82.05% (95%CI: 75.93–87.17%), but positive and negative likelihood ratios were poor. Therefore, preoperative plasma fibrinogen level in hip-arthroplasty patients was not associated with the need for blood-product transfusion.-
Descrição: dc.descriptionDepartment of Surgical Specialties and Anesthesiology School of Medicine Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionSão Vicente de Paulo Hospital, RS-
Descrição: dc.descriptionDepartment of Internal Medicine School of Medicine Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionDepartment of Surgical Specialties and Anesthesiology School of Medicine Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionDepartment of Internal Medicine School of Medicine Universidade Estadual Paulista (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationDiagnostics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanesthesia-
Palavras-chave: dc.subjectblood transfusion-
Palavras-chave: dc.subjectblood-coagulation tests-
Palavras-chave: dc.subjectfibrinogen-
Palavras-chave: dc.subjectorthopedic surgeries-
Título: dc.titlePlasma Fibrinogen as a Predictor of Perioperative-Blood-Component Transfusion in Major-Nontraumatic-Orthopedic-Surgery Patients: A Cohort Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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