The + 3010/C single nucleotide polymorphism (rs1710) at the HLA-G 3′ untranslated region is associated with a short transcript exhibiting a deletion of 92 nucleotides

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorService de Recherches en Hémato-ImmunologieHôpital Saint-Louis-
Autor(es): dc.contributorUniversité Paris Cité-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorPaes, Gabriela Sato-
Autor(es): dc.creatorda Silva, Isabelle Mira-
Autor(es): dc.creatorMoreau, Philippe-
Autor(es): dc.creatorDonadi, Eduardo A.-
Data de aceite: dc.date.accessioned2025-08-21T15:28:07Z-
Data de disponibilização: dc.date.available2025-08-21T15:28:07Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00251-023-01297-6-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249044-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249044-
Descrição: dc.descriptionThe physiological expression of HLA-G is mainly observed in the placenta, playing an essential role in maternal–fetal tolerance. Among the HLA-G mRNA alternative transcripts, the one lacking 92 bases at the HLA-G 3′ untranslated region (3′UTR), the 92bDel transcript, is more stable, is associated with increased HLA-G soluble levels, and was observed in individuals presenting a 14 bp insertion (14 bp+) at the 3′UTR. We investigated the presence of the 92bDel transcript in placenta samples, correlating its expression levels with the HLA-G polymorphisms at the 3′UTR. The 14 bp+ allele correlates with the presence of the 92bDel transcript. However, the polymorphism triggering this alternative splicing is the + 3010/C allele (rs1710, allele C). Most 14 bp+ haplotypes (UTR-2/-5/-7) present allele + 3010/C. However, 14 bp− haplotypes such as UTR-3 are also associated with + 3010/C, and the 92bDel transcript can be detected in homozygous samples for the 14 bp- allele carrying at least one copy of UTR-3. The UTR-3 haplotype is associated with alleles G*01:04 and the HLA-G lineage HG0104, which is a high-expressing lineage. The only HLA-G lineage that is not likely to produce this transcript is HG010101, associated with the + 3010/G allele. This functional difference may be advantageous, considering the high worldwide frequency of the HG010101 lineage. Therefore, HLA-G lineages are functionally distinct regarding the 92bDel transcript expression, and the 3010/C allele triggers the alternative splicing that produces this shorter and more stable transcript.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Pathology School of Medicine São Paulo State University (Unesp)-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory (GeMBio) – Experimental Research Unit School of Medicine São Paulo State University (Unesp)-
Descrição: dc.descriptionCommissariat À L’Energie Atomique Et Aux Energies Alternatives Direction de La Recherche Fondamentale Institut de Biologie François Jacob Service de Recherches en Hémato-ImmunologieHôpital Saint-Louis-
Descrição: dc.descriptionU976 HIPI Unit ISRL Université Paris Cité-
Descrição: dc.descriptionDivision of Clinical Immunology Department of Medicine Ribeirão Preto Medical School University of São Paulo (USP), SP, CEP-
Descrição: dc.descriptionDepartment of Pathology School of Medicine São Paulo State University (Unesp)-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory (GeMBio) – Experimental Research Unit School of Medicine São Paulo State University (Unesp)-
Descrição: dc.descriptionFAPESP: 13/17084-2-
Descrição: dc.descriptionFAPESP: 17/14345-0-
Formato: dc.format155-160-
Idioma: dc.languageen-
Relação: dc.relationImmunogenetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject3′UTR-
Palavras-chave: dc.subject92 base deletion-
Palavras-chave: dc.subjectAlternative splicing-
Palavras-chave: dc.subjectAlternative transcript-
Palavras-chave: dc.subjectExpression-
Palavras-chave: dc.subjectHLA-G-
Palavras-chave: dc.subjectPolymorphism-
Título: dc.titleThe + 3010/C single nucleotide polymorphism (rs1710) at the HLA-G 3′ untranslated region is associated with a short transcript exhibiting a deletion of 92 nucleotides-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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