Immunological evaluation of young unvaccinated patients with Turner syndrome after COVID-19

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstituto de Investigação em Imunologia - Instituto Nacional de Ciências e Tecnologia-iii-INCT-
Autor(es): dc.creatorde Castro, Mateus V.-
Autor(es): dc.creatorSilva, Monize V.R.-
Autor(es): dc.creatorOliveira, Luana de M.-
Autor(es): dc.creatorGozzi-Silva, Sarah C.-
Autor(es): dc.creatorNaslavsky, Michel S.-
Autor(es): dc.creatorScliar, Marilia O.-
Autor(es): dc.creatorMagalhães, Monize L.-
Autor(es): dc.creatorda Rocha, Katia M.-
Autor(es): dc.creatorNunes, Kelly-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorMagawa, Jhosiene Y.-
Autor(es): dc.creatorSantos, Keity S.-
Autor(es): dc.creatorCunha-Neto, Edecio-
Autor(es): dc.creatorSato, Maria N.-
Autor(es): dc.creatorZatz, Mayana-
Data de aceite: dc.date.accessioned2025-08-21T21:23:06Z-
Data de disponibilização: dc.date.available2025-08-21T21:23:06Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijid.2023.01.042-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249043-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249043-
Descrição: dc.descriptionObjectives: The X-chromosome contains the largest number of immune-related genes, which play a major role in COVID-19 symptomatology and susceptibility. Here, we had a unique opportunity to investigate, for the first time, COVID-19 outcomes in six unvaccinated young Brazilian patients with Turner syndrome (TS; 45, X0), including one case of critical illness in a child aged 10 years, to evaluate their immune response according to their genetic profile. Methods: A serological analysis of humoral immune response against SARS-CoV-2, phenotypic characterization of antiviral responses in peripheral blood mononuclear cells after stimuli, and the production of cytotoxic cytokines of T lymphocytes and natural killer cells were performed in blood samples collected from the patients with TS during the convalescence period. Whole exome sequencing was also performed. Results: Our volunteers with TS showed a delayed or insufficient humoral immune response to SARS-CoV-2 (particularly immunoglobulin G) and a decrease in interferon-γ production by cluster of differentiation (CD)4+ and CD8+ T lymphocytes after stimulation with toll-like receptors 7/8 agonists. In contrast, we observed a higher cytotoxic activity in the volunteers with TS than the volunteers without TS after phorbol myristate acetate/ionomycin stimulation, particularly granzyme B and perforin by CD8+ and natural killer cells. Interestingly, two volunteers with TS carry rare genetic variants in genes that regulate type I and III interferon immunity. Conclusion: Following previous reports in the literature for other conditions, our data showed that patients with TS may have an impaired immune response against SARS-CoV-2. Furthermore, other medical conditions associated with TS could make them more vulnerable to COVID-19.-
Descrição: dc.descriptionHuman Genome and Stem Cell Research Center University of São Paulo, São Paulo-
Descrição: dc.descriptionLaboratório de Investigação em Dermatologia e Imunodeficiências LIM 56 Instituto de Medicina Tropical Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo-
Descrição: dc.descriptionDepartamento de Dermatologia Faculdade de Medicina da Universidade de São Paulo, São Paulo-
Descrição: dc.descriptionDepartamento de Imunologia Instituto de Ciências Biomédicas Universidade de São Paulo, São Paulo-
Descrição: dc.descriptionDepartment of Genetics and Evolutionary Biology Biosciences Institute University of São Paulo, São Paulo-
Descrição: dc.descriptionSchool of Medicine Universidade Estadual Paulista-
Descrição: dc.descriptionLaboratório de Imunologia Instituto do Coração (InCor) LIM19 Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo-
Descrição: dc.descriptionInstituto de Investigação em Imunologia - Instituto Nacional de Ciências e Tecnologia-iii-INCT, São Paulo-
Descrição: dc.descriptionDepartamento de Clínica Médica Disciplina de Alergia e Imunologia Clínica Faculdade de Medicina da Universidade de São Paulo, São Paulo-
Descrição: dc.descriptionSchool of Medicine Universidade Estadual Paulista-
Formato: dc.format207-215-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Infectious Diseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectSARS-CoV-2-
Palavras-chave: dc.subjectTurner syndrome-
Palavras-chave: dc.subjectX-chromosome-
Título: dc.titleImmunological evaluation of young unvaccinated patients with Turner syndrome after COVID-19-
Tipo de arquivo: dc.typelivro digital-
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