Evidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversité de Paris-
Autor(es): dc.creatorOliveira-Caramez, Maria Luiza de-
Autor(es): dc.creatorVeiga-Castelli, Luciana-
Autor(es): dc.creatorSouza, Andreia S.-
Autor(es): dc.creatorCardili, Renata Nahas-
Autor(es): dc.creatorCourtin, David-
Autor(es): dc.creatorFlória-Santos, Milena-
Autor(es): dc.creatorDonadi, Eduardo-
Autor(es): dc.creatorGiuliatti, Silvana-
Autor(es): dc.creatorSabbagh, Audrey-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorMendes-Junior, Celso Teixeira-
Data de aceite: dc.date.accessioned2025-08-21T16:39:00Z-
Data de disponibilização: dc.date.available2025-08-21T16:39:00Z-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-07-29-
Data de envio: dc.date.issued2023-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cells12040630-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/249042-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/249042-
Descrição: dc.descriptionVitiligo is the most frequent cause of depigmentation worldwide. Genetic association studies have discovered about 50 loci associated with disease, many with immunological functions. Among them is HLA-G, which modulates immunity by interacting with specific inhibitory receptors, mainly LILRB1 and LILRB2. Here we investigated the LILRB1 and LILRB2 association with vitiligo risk and evaluated the possible role of interactions between HLA-G and its receptors in this pathogenesis. We tested the association of the polymorphisms of HLA-G, LILRB1, and LILRB2 with vitiligo using logistic regression along with adjustment by ancestry. Further, methods based on the multifactor dimensionality reduction (MDR) approach (MDR v.3.0.2, GMDR v.0.9, and MB-MDR) were used to detect potential epistatic interactions between polymorphisms from the three genes. An interaction involving rs9380142 and rs2114511 polymorphisms was identified by all methods used. The polymorphism rs9380142 is an HLA-G 3′UTR variant (+3187) with a well-established role in mRNA stability. The polymorphism rs2114511 is located in the exonic region of LILRB1. Although no association involving this SNP has been reported, ChIP-Seq experiments have identified this position as an EBF1 binding site. These results highlight the role of an epistatic interaction between HLA-G and LILRB1 in vitiligo pathogenesis.-
Descrição: dc.descriptionDepartamento de Genética Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, SP-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory School of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, SP-
Descrição: dc.descriptionInstitut de Recherche pour le Développement UMR 261 MERIT Université de Paris-
Descrição: dc.descriptionDepartamento de Enfermagem Materno-Infantil e Saúde Pública—(EERP/ERM) Universidade de São Paulo, SP-
Descrição: dc.descriptionPathology Department School of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionLaboratório de Pesquisas Forenses e Genômicas Departamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo, SP-
Descrição: dc.descriptionMolecular Genetics and Bioinformatics Laboratory School of Medicine São Paulo State University (UNESP), SP-
Descrição: dc.descriptionPathology Department School of Medicine São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationCells-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectancestry-
Palavras-chave: dc.subjectBrazil-
Palavras-chave: dc.subjectILT-2-
Palavras-chave: dc.subjectILT-4-
Palavras-chave: dc.subjectLILRB2-
Palavras-chave: dc.subjectSNPforID-
Título: dc.titleEvidence for Epistatic Interaction between HLA-G and LILRB1 in the Pathogenesis of Nonsegmental Vitiligo-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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